Naslov
Antioxidants and Endothelial Dysfunction in Young and Elderly People : Is FMD Useful to Assess Acute Effects?

Autori
Tsikas, Dimitrios ; Flentje, Markus ; Niemann, Jonas ; Böhmer, Anke ; Modun, Darko

Izvornik
Hypertension (Dallas, Tex.) (0194-911X) 60 (2012), 1; E5-e5

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo uredniku, znanstveni

Ključne riječi
antioxidants; FMD; oxidative stress; nitric oxide; nitrite

Sažetak
Wray and colleagues1 reported that acute consumption of an antioxidant cocktail containing vitamin C, vitamin E and alpha-lipoic acid by healthy subjects had diametrically different effects on FMD: in elderly people FMD increased, while in young people FMD decreased, as compared to the respective placebo groups. The opposite effects are difficult to interpret and to reconcile with the measured biomarkers of oxidative stress and nitric oxide (NO) synthesis/bioavailability. Nebivolol, a vasodilatator and antioxidant, given to healthy young volunteers (25 years of age) at a therapeutic dose (5 mg per day for 7 days), decreased oxidative stress compared to placebo. This observation indicates that basal oxidative stress can be reduced even in healthy young subjects below basal levels. This contradicts the findings by Wray et al which show even increases in oxidative stress and decreases in FMD in young people. Possible conclusions that could be drawn from that study is that the FMD technique may not be reliable to study acute effects of antioxidants on endothelial function and that its informational value is rather low. Plethysmography, in combination with accurate analytical assays for nitrite and oxidative stress biomarkers, is considerably more useful to measure reactive hyperemia and endothelial function in clinical studies on antioxidants.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA