Naslov
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity

Autori
Stanietsky, Noa ; Šimić, Hrvoje ; Arapović, Jurica ; Toporik, Amir ; Levy, Ofer ; Novik, Amit ; Levinec, Zurit ; Beimanc, Meirav ; Dassac, Liat ; Achdout, Hagit ; Stern-Ginossar, Noam ; Tsukermana, Pinhas ; Jonjic, Stipan ; Mandelboim, Ofer

Izvornik
Proceedings of the National Academy of Sciences of the United States of America (0027-8424) 106 (2009), 42; 17858-17863

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
NK cels ; TIGIT ; PVR ; Nectin-2

Sažetak
NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of the inhibitory receptors bind MHC class I proteins and are expressed in a variegated fashion. It was recently shown that TIGIT, a new protein expressed by T and NK cells binds to PVR and PVR-like receptors and inhibits T cell activity indirectly through the manipulation of DC activity. Here, we show that TIGIT is expressed by all human NK cells, that it binds PVR and PVRL2 but not PVRL3 and that it inhibits NK cytotoxicity directly through its ITIM. Finally, we show that TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytoxicity thus providing an “alternative self” mechanism for MHC class I inhibition.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Israel–Croatia Research Grant

POVEZANOST RADA