Naslov
Solvent-Free Polymorphism Control in a Covalent Mechanochemical Reaction

Autori
Cinčić, Dominik ; Brekalo, Ivana ; Kaitner, Branko

Izvornik
Crystal growth & design (1528-7483) 12 (2012), 1; 44-48

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Seeding-assisted grinding; polymorphism control; mechanochemical reaction; Schiff base
(Seeding-assisted grinding; polymorphism control; mechanochemical Reaction; Schiff base)

Sažetak
Four crystal modifications of a Schiff base derived from 2-hydroxy-1-naphthaldehyde and 2- aminobenzonitrile have been obtained by conventional solution-based methods. Three polymorphs out of four can be synthesized under solvent-free conditions. Herein we report simultaneous solvent-free covalent synthesis and polymorphism control of a single component system using mechanochemistry via neat grinding and seeding-assisted grinding, i.e. neat grinding in the presence of seed crystals. We describe the important role of seed crystals in directing the supramolecular organization of the product of covalent solvent-free reaction toward the intended polymorphic outcome. Single crystal X-ray analysis of the four crystal forms revealed conformational differences in molecules. Polymorphs display interesting and remarkably different molecular packing features via C−H···N and C−H···O interactions: 1D chains in form I, a 2D-network in forms III and IV, and a 3D-network in form II.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA