Naslov
Influence of Mannosylation on Immunostimulating Activity of Adamant-1-yl Tripeptide

Autori
Ribić, Rosana ; Habjanec, Lidija ; Frkanec, Ruža ; Vranešić, Branka ; Tomić, Srđanka

Izvornik
Chemistry & biodiversity (1612-1872) 9 (2012), 7; 1373-1381

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
mannose; adamant-1-yl tripeptide; immunostimulating activity; peptidoglycan monomer

Sažetak
The aim of this work was to prepare the mannosylated derivative of adamant-1-yl tripeptide (D-(Ad-1-yl)Gly-L-Ala-D-isoGln) in order to study the effects of mannosylation on adjuvant (immunostimulating) activity. Mannosylated adamant-1-yl tripeptide (Man-OCH2CH(CH3)CO-D-(Ad- 1-yl)Gly-L-Ala-D-isoGln) is non-pyrogenic, water- soluble and non-toxic compound. Adjuvant activity of mannosylated adamantyltripeptide was tested in the mouse model using ovalbumin as an antigen and in comparison to the parent tripeptide and peptidoglycan monomer (PGM, β-D-GlcNAc-(1→4)-D- MurNAc-L-Ala-D-isoGln-mesoDAP(εNH2)-D-Ala-D-Ala), a well known effective adjuvant. The mannosylation of adamantyltripeptide caused the amplification of its immunostimulating activity in such a way that it was comparable to that of PGM.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA