Naslov
Genome-wide expression analysis of peripheral blood identifies candidate biomarkers for schizophrenia.

Autori
Rojnic Kuzman, Martina ; Medved, Vesna ; Terzić, Janoš ; Božina, Nada ; Krainc, Dimitri

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Schizophrenia Research / - , 2008

Skup
World congress of psychiatric Genetics

Mjesto i datum
Osaka, Japan, 11.10.2008. - 15.10.2008

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
genetic expression; blood; biomarkers; schizophrenia; drug naive

Sažetak
The aim of this study was to analyze gene expression in blood of patients with newly-diagnosed schizophrenia during their first psychotic episode and subsequent remission. Whole blood samples were obtained from 32 untreated patients presenting with their first psychotic episode suggestive of schizophrenia and 32 age- and gender-matched controls. In summary, we identified changes of gene expression from peripheral blood which might help discriminate patients with schizophrenia from controls. While these results are promising, especially for DAAM2 whose polymorphic variants have been found significantly associated with schizophrenia, it will be important to analyze larger cohorts of patients in order to firmly establish changes in gene expression as blood markers of schizophrenia.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA