Naslov
Combined oral treatment with racemic and meso-2, 3-dimercaptosuccinic acid for removal of mercury in rats

Autori
Kostial, Krista ; Restek-Samaržija, Nada ; Blanuša, Maja ; Piasek, Martina ; Jones, Mark ; Singh, Pramod

Izvornik
Pharmacology & toxicology (0901-9928) 81 (1997), 5; 242-244

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Meso-2; 3-dimercaptosuccinic acid; racemic-2; 3-dimercaptosuccinic acid; mercury-203; whole body retention; liver; kidney; brain; rat

Sažetak
Racemic- dimercaptosuccinic acid (DMSA) was found more efficient than meso-isoform in enhancing the removal of mercury in rats. However, racemic-DMSA has recently been found more toxic. The efficiency of combined oral treatment with the two isoforms of DMSA for removal of mercury has now been evaluated. Female albino rats were treated four days orally with meso- (M) and/or racemic- (R) DMSA (1 mmol/kg each), five days after a single intraperitoneal administration of 203ČHg with 0.5 mg HgCl_2/kg. Animals were divided into six groups according to the number of treatments with each isomer: control (untreated), 4M, 1R+3M, 2R+1M, and 4R. The whole body, kidney, liver and brain mercury contents were measured nine days after 203ČHg administration. In all treated groups retention in the whole body and kidneys was greatly reduced. The groups treated with racemic-DMSA, regardless of the number of doses, showed a greater removal of mercury than the group treated with meso-DMSA alone (4M). All treatments were less efficient in reducing liver retention, and the brain retention was not effected. It was concluded that even a single application of the more toxic racemic-DMSA during four day oral treatment regimen is sufficient to improve the removal by meso-DMSA of mercury from rats.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA