Naslov
Acid–base and electrochemical properties of manganese meso(ortho- and meta-N-ethylpyridyl)porphyrins : potentiometric, spectrophotometric and spectroelectrochemical study of protolytic and redox equilibria

Autori
Weitner, Tin ; Budimir, Ana ; Kos, Ivan ; Batinić-Haberle, Ines ; Biruš, Mladen

Izvornik
Dalton transactions (1477-9226) 39 (2010), 48; 11568-11576

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
manganese meso-N-ethylpyridylporphyrins; spectroelectrochemistry; protolytic equilibrium; redox equilibrium

Sažetak
The difference in electrostatics and reduction potentials between manganese ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin (MnTE-2-PyP) and manganese meta-tetrakis(N-ethylpyridinium-3- yl)porphyrin (MnTE-3-PyP) is a challenging topic, particularly because of the high likelihood for their clinical development. Hence, a detailed study of the protolytic and electrochemical speciation of MnII–IVTE-2-PyP and MnII–IVTE-3-PyP in a broad pH range has been performed using the combined spectrophotometric and potentiometric methods. The results reveal that in aqueous solutions within the pH range ~2–13 the following species exist: (H2O)MnIITE-m-PyP4+, (HO)MnIITE-m-PyP3+, (H2O)2MnIIITE-m-PyP5+, (HO)(H2O)MnIIITE-m-PyP4+, (O)(H2O)MnIIITE-m-PyP3+, (O)(H2O)MnIVTE-m-PyP4+ and (O)(HO)MnIVTE-m-PyP3+ (m = 2, 3). All the protolytic equilibrium constants that include the accessible species as well as the thermodynamic parameters for each particular protolytic equilibrium have been determined. The corresponding formal reduction potentials related to the reduction of the above species and the thermodynamic parameters describing the accessible reduction couples were calculated as well.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija

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