Naslov
Relationship between autoantibodies combination, metabolic syndrome and its components in autoimmune diabetes in adults

Autori
Bulum, Tomislav ; Blaslov, Kristina ; Knežević-Ćuća, Jadranka ; Duvnjak, Lea

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Diabetologia 2014 ; 57 (Suppl. 1): 186- 186. / - , 2014

Skup
50th EASD Annual Meeting

Mjesto i datum
Beč, Austrija, 15.09.2014. - 19.09.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
adult onset diabetes mellitus; autoimmunity; metabolic syndrome

Sažetak
Our data support the suggestion that simultaneous Abs positivity and their titre value represents an important determinant in clinical phenotype of LADA patients. The simultaneous double (GAD and ICA) and triple (GAD, ICA and IA2) Abs positivity seems to reflect T1DM patient’s phenotype. Our results also implicate the importance of IA-2 determination for this purpose as IA-2 positivity in combination with other Abs does not appear to be as rare as previously reported. Additionally, simultaneous GAD, ICA and IA-2 Abs positivity might be used to identify patients with more severe form of 'cell autoimmunity whose residual' cell function might be preserved by early insulinisation. The highest prevalence of MS in the group with single GAD positivity suggest that those patients are phenotypically closer to T2DM.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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