Naslov
Nonalcoholic steatohepatitis: Review of current and novel diagnostic options

Autori
Duvnjak, Marko ; Stojsavljević, Sanja

Izvornik
Bosnian journal of basic medical sciences (1512-8601) 11 (2011), 1; 171-176

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, ostalo

Ključne riječi
nonalcoholic steatohepatitis; nonalcoholic fatty liver disease; fibrosis; steatosis; laboratory test; imaging techniques

Sažetak
Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) characterized with histological findings of hepatic steatosis, inflammation and cellular damage. There is an ongoing epidemic of metabolic syndrome, and NAFLD, being the hepatic manifestation of metabolic syndrome, not surprisingly, is currently the leading cause of chronic liver disease in the Western world. The main goal is to in due time, before the onset of more severe complications, diagnose and differentiate simple steatosis from NASH. Liver biopsy has been, and still is, the ‘’golden standard’’ for proper diagnosis of NAFLD although it is associated with certain unavoidable risks, complications and limitation. Therefore, new markers of fibrosis and steatosis such as cytokeratin-18, plasma pentraxine 3, serum prolidase enzyme activity, plasma soluble receptors for advanced gylcation, different test panels and new diagnostic techniques are being evaluated to match the successfulness of liver biopsy and thus replace it.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA