Naslov
THE INFLUENCE OF ENZYME MATRIX METALLOPROTEINASE-9 IN THE PATHOGENESIS OF ATHEROSCLEROSIS

Autori
Mrakovčić-Šutić, Ines ; Brekalo, Zdrinko ; Kovačević, Miljenko ; Bulog, Aleksandar ; Mićović, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Autoimmunity Congress of Asia 2011

Mjesto i datum
Singapur, 17.11.2011. - 19.11.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
atherosclerosis; carotid artery; enzyme matrix metalloproteinases-9

Sažetak
The members of the matrix metalloproteinase (MMP) family are involved in the pathogenesis of vascular diseases such as atherosclerosis, varicose veins, hypertension, abdominal aortic aneurysm, preeclampsia, etc. They play a crucial role in angiogenesis, vascular remodeling and the uterine and systemic vasodilatation during normal pregnancy in response to hemodynamic stimuli. Alterations in vascular tone are usually a result of changes in endothelial cell function, as well as increasing of neurohormonal stimulation or altered sensitivity of vascular smooth muscle. Chronic changes in vascular function lead to structural changes in the blood vessel architecture. The aim of the study: The aim of our study was to examine the values of enzyme matrix metalloproteinase-9 in urine in patients with atherosclerosis of carotid arteries, undergoing surgery, and compare to controls (healthy volunteers). Patients and methods: we analyzed 40 patients with atherosclerosis who were undergoing the surgical procedure. The method of enzyme immunoassay (ELISA) was used to determine enzyme expression of matrix metalloproteinase-9 (MMP-9). Statistical data were Calculated using computer program Statistica 7.1. Results: The patients with atherosclerosis had a statistically significantly elevated level of MMP-9 in the urine in comparison with healthy volunteers. Conclusion: Our data has showed a large increase in the enzyme MMP-9 in the urine of atherosclerotic patients, which can be an easy marker for the monitoring of the development of atherosclerosis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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