Pregled bibliografske jedinice broj: 555785
THE INFLUNCE OF POSTOPERATIVE PAIN MANAGEMENT TECHNIQUES ON THE INNATE IMMUNITY IN PATIENTS WITH COLORECTAL CANCER
THE INFLUNCE OF POSTOPERATIVE PAIN MANAGEMENT TECHNIQUES ON THE INNATE IMMUNITY IN PATIENTS WITH COLORECTAL CANCER // Godišnja skupština Hrvatskog imunološkog društva 2010 s međunarodnim sudjelovanjem
Mali Lošinj, Hrvatska, 2010. (predavanje, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 555785 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
THE INFLUNCE OF POSTOPERATIVE PAIN MANAGEMENT TECHNIQUES ON THE INNATE IMMUNITY IN PATIENTS WITH COLORECTAL CANCER
Autori
Mrakovčić-Šutić, Ines ; Golubović, Vesna ; Golubović, Snježana ; Sotošek Tokmadžić, Vlatka ; Petković, Marija
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
Godišnja skupština Hrvatskog imunološkog društva 2010 s međunarodnim sudjelovanjem
Mjesto i datum
Mali Lošinj, Hrvatska, 07.10.2010. - 10.10.2010
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Domaća recenzija
Ključne riječi
colorectal cancer; epidural analgesia; intravenous analgesia; perforin
Sažetak
During the postoperative recovery, accompanied with neuroendocrine, metabolic and immune alteration, chronic pain as a results of physical insults, inflammation, cancer, visceral pathologies and nerve damage represents one of the most important difficulties that confront surgical patients. Postoperative pain contributs to immunosupression as a result of interaction between central nervous and immune systems. The postoperatively activated hypotalamo-pituitary-adrenocortical and sympatoadrenal axis are important modulators of immune response. Cancer patients represent one of the most sensitive patients for analgesia and surgical stress with accompanied alteration of innate and aquired immune response. The aim of this study was to compare two postoperative pain management techniques in patients undergoing colorectal cancer surgery on expression of cytolitic molecule perforin in peripheral blood mononuclear cells, as well as to analyze the relationship between the number of Treg and NKT cells and clinical outcomes of these patients. Methods: Phenotype of lymphocytes and perforin expression were analyzed using intracellular and surface immunofluoresecncy and flow cytometric analysis (FACSCalibur). Results: 20-30% of PBL in all examine group are perforin positive (total perforin is significantly higher in patients underwent epidural analgesia than in intravenous experimental group). Conclusions: human perforin is differentially expressed in distinct sub-populations of peripheral blood lymphocytes of patients with colorectal cancer, implicating the important role of postoperative pain management techniques on expression of perforin positive cells and their role in naïve immune response and cytotoxic activity of peripheral blood lymphocytes. The appropriate postoperative pain management can modulate immune response of these patients after colorectal surgery.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
062-0620096-0092 - Epiduralna analgezija i stanična imunost u bolesnika s kolorektalnim karcinomom (Golubović, Vesna, MZOS ) ( CroRIS)
062-0620096-0094 - Regulacijske T i NKT stanice u kontroli tumorskog rasta, opeklina i autoimunosti (Mrakovčić-Šutić, Ines, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Marija Petković
(autor)
Vesna Golubović
(autor)
Ines Mrakovčić-Šutić
(autor)
Vlatka Sotošek
(autor)
Snježana Golubović
(autor)