Naslov
Serotonin transporter gene polymorphisms in Crohn's disease patients

Autori
Grubelić Ravić, Katja ; Čuković Čavka, Silvija ; Anzulović, Dora ; Brinar, Marko ; Krznarić, Željko ; Sertić, Jadranka ; Božina, Nada ; Rojnić Kuzman, Martina ; Vucelić, Boris

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract book. 76:P3-9 / - , 2009

Skup
5. kongres Hrvatskog gastroenterološkog društva

Mjesto i datum
Dubrovnik, Hrvatska, 02.05.2009. - 05.05.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
serotonin; transport gene; Crohn's disease

Sažetak
Serotonin (5-HT) is an important factor in gut function, playing key roles in intestinal peristalsis, secretion, vasodilatation and sensory signalling. The serotoninselective reuptake transporter protein (SERT) terminates the action of 5-HT. Human SERT is encoded by a single gene on chromosome 17q11 ; two important polymorphic sites in the SERT gene are: variable number tandem repeats in the gene’ s second intron (SERTin2), and an insertion/deletion in the promoter region (SERTPR). Consistent with the effects of 5-HT in the gut, SERT polymorphisms could potentially be involved in the development of IBD. The aim of this study was to evaluate the possible role of SERT polymorphisms in pathogenesis of CD.

Izvorni jezik
Engleski

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