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Pregled bibliografske jedinice broj: 554671

Combined evaluation of bone marrow aspirate and biopsy is superior in the prognosis of multiple myeloma


Štifter, Sanja; Babarović, Emina; Valković, Toni; Seili-Bekafigo, Irena; Štemberger, Cristophe; Načinović, Antica; Lučin, Ksenija; Jonjić, Nives
Combined evaluation of bone marrow aspirate and biopsy is superior in the prognosis of multiple myeloma // Diagnostic pathology, 5 (2010), 30-1 doi:10.1186/1746-1596-5-30 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 554671 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Combined evaluation of bone marrow aspirate and biopsy is superior in the prognosis of multiple myeloma

Autori
Štifter, Sanja ; Babarović, Emina ; Valković, Toni ; Seili-Bekafigo, Irena ; Štemberger, Cristophe ; Načinović, Antica ; Lučin, Ksenija ; Jonjić, Nives

Izvornik
Diagnostic pathology (1746-1596) 5 (2010); 30-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
evaluation of bone marrow aspirate and biopsy; prognosis of multiple myeloma.

Sažetak
Estimation of plasma cell infiltrates in bone marrow aspirates (BMA) and bone marrow biopsy (BMB) is a standard method in the diagnosis and monitoring of multiple myeloma (MM). Plasma cell fraction in the bone marrow is therefore critical for the classification and optimal clinical management of patients with plasma cell dyscrasias. The aim of the study was to compare the percentage of plasma cells obtained by both methods with the patient clinical parameters and survival. This retrospective study included BMA and BMB of 59 MM patients. The conventional differential count was determined in BMA to estimate the percentage and cytologic grade of plasma cells. The pattern of neoplastic infiltration and percentage of plasma cells were estimated on CD138 immunostained BMB slides microscopically and by computer-assisted image analysis (CIA). Significantly higher values of plasma cell infiltrates were observed in pathologist (47.7 +/- 24.8) and CIA (44.1 +/- 30.6) reports in comparison with cytologist analysis (30.6 +/- 17.1 ; P < 0.001 and P < 0.0048, respectively). BMB assessment by pathologist counting and using CIA showed strongest correlation (r = 0.8 ; P < 0.0001). Correlation was also observed between the pathologist and cytologist counts (r = 0.321 ; P = 0.015) as well as comparing the percentage of plasma cells in BMA and CIA (r = 0.27 ; P = 0.05). Patients with clinical stage I/II had a significantly lower CIA plasma cell count than those with clinical stage III (P = 0.008). Overall survival was shorter in patients with more than 25% of atypical plasma cell morphology estimated in BMA (P = 0.05) and a higher percentage of tumor cell infiltrates estimated by the pathologist and CIA (P = 0.0341 and P = 0.013, respectively). Study results suggested the combined analyses to be useful as a routine procedure to achieve more accurate and informative diagnostic data.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
062-0620095-0078 - Uloga osteopontina u progresiji tumora (Lučin, Ksenija, MZOS ) ( CroRIS)
062-0620095-0079 - Uloga kemokina u patogenezi multiplog mijeloma (Valković, Toni, MZOS ) ( CroRIS)
062-0620095-0082 - REGULACIJSKI ČIMBENICI ANGIOGENEZE U PROGNOZI TUMORA (Jonjić, Nives, MZOS ) ( CroRIS)
062-1081872-0091 - Angiogeneza u agresivnih ne-Hodgkinovih limfoma (Duletić-Načinović, Antica, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju:

Štifter, Sanja; Babarović, Emina; Valković, Toni; Seili-Bekafigo, Irena; Štemberger, Cristophe; Načinović, Antica; Lučin, Ksenija; Jonjić, Nives
Combined evaluation of bone marrow aspirate and biopsy is superior in the prognosis of multiple myeloma // Diagnostic pathology, 5 (2010), 30-1 doi:10.1186/1746-1596-5-30 (međunarodna recenzija, članak, znanstveni)
Štifter, S., Babarović, E., Valković, T., Seili-Bekafigo, I., Štemberger, C., Načinović, A., Lučin, K. & Jonjić, N. (2010) Combined evaluation of bone marrow aspirate and biopsy is superior in the prognosis of multiple myeloma. Diagnostic pathology, 5, 30-1 doi:10.1186/1746-1596-5-30.
@article{article, author = {\v{S}tifter, Sanja and Babarovi\'{c}, Emina and Valkovi\'{c}, Toni and Seili-Bekafigo, Irena and \v{S}temberger, Cristophe and Na\v{c}inovi\'{c}, Antica and Lu\v{c}in, Ksenija and Jonji\'{c}, Nives}, year = {2010}, pages = {30-1-30-7}, DOI = {10.1186/1746-1596-5-30}, keywords = {evaluation of bone marrow aspirate and biopsy, prognosis of multiple myeloma.}, journal = {Diagnostic pathology}, doi = {10.1186/1746-1596-5-30}, volume = {5}, issn = {1746-1596}, title = {Combined evaluation of bone marrow aspirate and biopsy is superior in the prognosis of multiple myeloma}, keyword = {evaluation of bone marrow aspirate and biopsy, prognosis of multiple myeloma.} }
@article{article, author = {\v{S}tifter, Sanja and Babarovi\'{c}, Emina and Valkovi\'{c}, Toni and Seili-Bekafigo, Irena and \v{S}temberger, Cristophe and Na\v{c}inovi\'{c}, Antica and Lu\v{c}in, Ksenija and Jonji\'{c}, Nives}, year = {2010}, pages = {30-1-30-7}, DOI = {10.1186/1746-1596-5-30}, keywords = {evaluation of bone marrow aspirate and biopsy, prognosis of multiple myeloma.}, journal = {Diagnostic pathology}, doi = {10.1186/1746-1596-5-30}, volume = {5}, issn = {1746-1596}, title = {Combined evaluation of bone marrow aspirate and biopsy is superior in the prognosis of multiple myeloma}, keyword = {evaluation of bone marrow aspirate and biopsy, prognosis of multiple myeloma.} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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