Pregled bibliografske jedinice broj: 554671
Combined evaluation of bone marrow aspirate and biopsy is superior in the prognosis of multiple myeloma
Combined evaluation of bone marrow aspirate and biopsy is superior in the prognosis of multiple myeloma // Diagnostic pathology, 5 (2010), 30-1 doi:10.1186/1746-1596-5-30 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 554671 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Combined evaluation of bone marrow aspirate and biopsy is superior in the prognosis of multiple myeloma
Autori
Štifter, Sanja ; Babarović, Emina ; Valković, Toni ; Seili-Bekafigo, Irena ; Štemberger, Cristophe ; Načinović, Antica ; Lučin, Ksenija ; Jonjić, Nives
Izvornik
Diagnostic pathology (1746-1596) 5
(2010);
30-1
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
evaluation of bone marrow aspirate and biopsy; prognosis of multiple myeloma.
Sažetak
Estimation of plasma cell infiltrates in bone marrow aspirates (BMA) and bone marrow biopsy (BMB) is a standard method in the diagnosis and monitoring of multiple myeloma (MM). Plasma cell fraction in the bone marrow is therefore critical for the classification and optimal clinical management of patients with plasma cell dyscrasias. The aim of the study was to compare the percentage of plasma cells obtained by both methods with the patient clinical parameters and survival. This retrospective study included BMA and BMB of 59 MM patients. The conventional differential count was determined in BMA to estimate the percentage and cytologic grade of plasma cells. The pattern of neoplastic infiltration and percentage of plasma cells were estimated on CD138 immunostained BMB slides microscopically and by computer-assisted image analysis (CIA). Significantly higher values of plasma cell infiltrates were observed in pathologist (47.7 +/- 24.8) and CIA (44.1 +/- 30.6) reports in comparison with cytologist analysis (30.6 +/- 17.1 ; P < 0.001 and P < 0.0048, respectively). BMB assessment by pathologist counting and using CIA showed strongest correlation (r = 0.8 ; P < 0.0001). Correlation was also observed between the pathologist and cytologist counts (r = 0.321 ; P = 0.015) as well as comparing the percentage of plasma cells in BMA and CIA (r = 0.27 ; P = 0.05). Patients with clinical stage I/II had a significantly lower CIA plasma cell count than those with clinical stage III (P = 0.008). Overall survival was shorter in patients with more than 25% of atypical plasma cell morphology estimated in BMA (P = 0.05) and a higher percentage of tumor cell infiltrates estimated by the pathologist and CIA (P = 0.0341 and P = 0.013, respectively). Study results suggested the combined analyses to be useful as a routine procedure to achieve more accurate and informative diagnostic data.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
062-0620095-0078 - Uloga osteopontina u progresiji tumora (Lučin, Ksenija, MZOS ) ( CroRIS)
062-0620095-0079 - Uloga kemokina u patogenezi multiplog mijeloma (Valković, Toni, MZOS ) ( CroRIS)
062-0620095-0082 - REGULACIJSKI ČIMBENICI ANGIOGENEZE U PROGNOZI TUMORA (Jonjić, Nives, MZOS ) ( CroRIS)
062-1081872-0091 - Angiogeneza u agresivnih ne-Hodgkinovih limfoma (Duletić-Načinović, Antica, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Antica Duletić-Načinović
(autor)
Sanja Štifter
(autor)
Emina Babarović
(autor)
Toni Valković
(autor)
Irena Seili-Bekafigo
(autor)
Nives Jonjić
(autor)
Ksenija Jurinović
(autor)
Poveznice na cjeloviti tekst rada:
Pristup cjelovitom tekstu rada doi www.ncbi.nlm.nih.gov www.diagnosticpathology.orgCitiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE