Naslov
Vagus nerve stimulation in the treatment of patients with pharmacoresistant epilepsy: our expiriences

Autori
Hajnšek, Sanja ; Petelin, Željka ; Mrak, Goran ; Desnica, Andrej ; Paladino, Josip ; Poljaković, Zdravka ; Šulentić, Vlatko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Acta clinica Croatica, suppl. 1 / Rotim, Krešimir ; Ledić, Darko - Zagreb : Klinički bolnički centar Zagreb (KBC Zagreb), 2011, 45-46

Skup
6th Congress of the Croatian neurosurgical society and the Joint Meeting with the Slovenian Neurosurgical Society

Mjesto i datum
Opatija, Hrvatska, 25.05.2011. - 28.05.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
vagus nerve stimulation; pharmacoresistant epilepsy

Sažetak
Aim of the study: We have studied the efficacy of vagus nerve stimulation (VNS) in patients with pharmacoresistant epilepsy hospitalized in the Neurology Department of the University Hospital Centre Zagreb. Methods: From 1997 do 2001 we have implanted VNS in 11 patients with pharmacoresistant epilepsy, who were magnetic resonance imaging (MRI) negative and from 2007 to 2010 in 23 patients with pharmacoresistant epilepsy, 21 of them were MRI positive, and were inoperable due to localisation of the pathomorphologic changes (ganglioglioma, hamartoma, various types of cortical dysplasia, porencephalic cysts, bilateral hippocampal sclerosis), 2 were MRI negative. In the group of MRI negative patients 1 patient had complex partial seizures (CPS), 6 patients had CPS with secondary generalisation, 2 patients had primary generalized epilepsy (PGE), one patient had PGE and CPS, and 3 patients had Lennox-Gastaut syndrome (LGS). In the group of MRI positive patients three patients had elementary partial seizures (EPS) and CPS with secondary generalisation, 16 patients had CPS with secondary generalisation, and 2 patients had CPS with secondary generalisation as well as atonic seizures. Results and conclusions: After implantation of VNS there was significant decrease in mean seizure frequency in both group of patients (in the group of MRI positive patients around 65%, and in the group of MRI negative patients around 75%). The most frequent side effects were hoarseness, throat pain and cough, but they were mild and transitory. VNS was effective mode of therapy in our group of patients with pharmacoresistant epilepsy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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