Naslov
The role of NKT cells in experimental autoimmune diabetes mellitus

Autori
Mrakovčić-Šutić, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Zbornik 5. hrvatskog endokrinološkog kongresa s međunarodnim sudjelovanjem / - , 2011

Skup
5. hrvatski endokrinološki kongres s međunarodnim sudjelovanjem

Mjesto i datum
Pula, Hrvatska, 28.09.2011. - 02.10.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
autoimmune diabates mellitus; innate immunity; NKT cells

Sažetak
NKT cells represent a type of T cells that share the common features of natural killer cells (NK) and conventional T cells. NKT cells are involved in the regulation of innate immune responses, tumor rejection, posttransplantation immunotherapy, immunological survival, control of autoimmune disease (diabetes mellitus, multiple sclerosis, SLE, myasthenia gravis, asthma, RA and others), and in many pathological conditions, in which regulate viral infection in vivo and tumor growth. These cells can play protective, but also defensive role in the progression of certain autoimmune diseases such as diabetes, lupus, atherosclerosis and asthma. NKT deficiencies in humans are associated with the development of autoimmune diseases, such as insulin dependent diabetes mellitus, as is the emergence of some cancers. Autoimmune diseases are controlled by genetic factors and environmental factors. Material and Methods: Streptozotocin was given to experimental animals to caused autoimmune diabetes mellitus, and by flow cytometry techniques were determined phenotypic characteristics of peripheral blood and of lymphatic tissues (liver and spleen). Results: Streptozotocin-induced diabetes mellitus caused significant changes in innate and acquired immunity. Conclusion: The results obtained from these studies indicate the importance of innate and acquired immunity in autoimmune disease and we can talk about NKT-based immunotherapy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA