BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy

Marić, Ivana; Kučić, Natalia; Turk, Tamara; Smoljan, Ivana; Grahovac, Blaženka; Zoričić Cvek, Sanja; Ćelić, Tanja; Bobinac, Dragica; Vukičević, Slobodan

doi:10.1152/ajpgi.00244.2011

Pregled bibliografske jedinice broj: 552856

BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy

Marić, Ivana; Kučić, Natalia; Turk, Tamara; Smoljan, Ivana; Grahovac, Blaženka; Zoričić Cvek, Sanja; Ćelić, Tanja; Bobinac, Dragica; Vukičević, Slobodan

BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy // American journal of physiology-gastrointestinal and liver physiology, 302 (2012), 10; G1151-G1162 doi:10.1152/ajpgi.00244.2011 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 552856 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
BMP signaling pathway in the rat model of TNBS colitis following BMP7 therapy

Autori
Marić, Ivana ; Kučić, Natalia ; Turk, Tamara ; Smoljan, Ivana ; Grahovac, Blaženka ; Zoričić Cvek, Sanja ; Ćelić, Tanja ; Bobinac, Dragica ; Vukičević, Slobodan

Izvornik
American journal of physiology-gastrointestinal and liver physiology (0193-1857) 302 (2012), 10; G1151-G1162

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BMPs; TNBS colitis; Inflammatory bowel disease; Smad proteins

Sažetak
Beyond stimulating bone formation, the bone morphogenetic proteins (BMPs) are important in development, inflammation and malignancy of the gut. We have previously shown that BMP7 has a regenerative, anti-inflammatory and anti- proliferative effect on experimental inflammatory bowel disease (IBD) in rat. To further investigate the BMP signaling pathway we monitored the effect of BMP7 therapy on the BMP signaling components in rat colon during different stages of experimentally induced colitis by 2, 4, 6- trinitrobenzene sulfonic acid (TNBS). The results showed increased of BMP2 and -7 expression in the chronic phase of colitis. BMP7 treatment slightly enhanced BMP4, -6 and -7, and suppressed the BMP2 expression. CTGF and noggin expression was elevated in TNBS colitis, and slightly decreased upon BMP7 therapy. BMP receptor I expression was unchanged, while BMP receptor II was increased at day 14 and 30 of TNBS inflammation, and decreased following BMP7 therapy. BMP7 increased Smad1, Smad3 and Smad4. Inhibitory Smads were increased in colitis, but not in rats treated with BMP7. We conclude that BMP signaling is preserved in colon during TNBS-induced colonic inflammation and could be modulated with BMP7, suggesting that IBD is a reversible process with self-recovery features.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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