Naslov
Cytoskeleton: structural, functional, and pathobiochemical aspects

Autori
Barišić, Karmela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Kongres hrvatskih biokemičara i molekularnih biologa uz međunarodno sudjelovanje, HB2000; Program i knjiga sažetaka / Floegel, Mirna - Zagreb : Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2000

Skup
Kongres hrvatskih biokemičara i molekularnih biologa uz međunarodno sudjelovanje, HB2000

Mjesto i datum
Zagreb, Hrvatska, 13.10.2000. - 15.10.2000

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
cytoskeleton; actin filaments; microtubules; intermediate filaments; disorders

Sažetak
A network of fibers, cytoskeleton, is composed of three fiber systems (microfilaments, microtubules, and intermediate filament). The cytoskeleton is responsible for many fundamental processes of the cell; for giving a cell its shape, for generating the forces required for cell migration, and for providing a framework to which cellular organelles are attached. In the cell, the actin cytoskeleton is a network of filaments and bundles in equilibrium with a pool of actin monomers. Actin network and bundles are held together by actin-cross-linking proteins (fimbrin, ƒŃ-actinin, spectrin, dystrophin etc.) Actin filaments form a framework to which the plasma membrane is attached through membrane-microfilament binding proteins. Microtubules are built of tubulin, a heterodimer of one ƒŃ and one ƒŇ subunit. Microtubules act as a track along which vesicles, Golgy vesicles, and small particles move or togheter with other proteins form axonemes of cilia and flagella. They are also the structural elements of mitotic spindle. Intermediate filaments (desmin, keratin, lamin etc.) determine cellular structure and are involved in cell-cell and cell-matrix interactions. Cytoskeletal proteins are involved in pathogenesis of some disorders. Microfilaments are involved in certain pathogenetic processes on account of defects in their associated proteins (dystrophin is defective in Duchenne muscular dystrophy; synapsin is defective in Rett syndrome; spectrin is defective in congenital hemolytic anemia etc.). Intermediate filaments related diseases are also known (epidermolysis bullosa, Mallory bodies etc.). There are evidences that cytoskeletal components play the crucial role in Alzheimer disease, intrahepatic cholestasis, and pemphigus.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA