Naslov
The insulin-like growth factor 2 receptor gene Gly1619Arg polymorphism and idiopathic recurrent spontaneous abortion.

Autori
Pereza, Nina ; Ostojić, Saša ; Volk, Marija ; Maver, Aleš ; Kapović, Miljenko ; Peterlin, Borut

Izvornik
Journal of Maternal-Fetal & Neonatal Medicine (1476-7058) 25 (2012), 4; 429-431

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
pregnancy; gene polymorphisms; placenta; miscarriage

Sažetak
The insulin-like growth factor 2 (IGF2) and its receptor (IGF2R) are important regulators of placental function and fetal growth. Our aim was to investigate the association between IGF2R gene Gly1619Arg G>A polymorphism and recurrent spontaneous abortion (RSA). Methods. Polymerase chain reaction and restriction fragment length polymorphism methods were performed to identify the genotypes in 149 couples with a history of at least three consecutive spontaneous abortions and 149 age-matched, unrelated, and fertile couples. Results. There were no statistically significant differences in genotype or allele frequency among the couples with RSA and healthy controls. Conclusions. We found no evidence that the IGF2R Gly1619Arg variation is associated with RSA.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA