Naslov
Long Term Sensorineural Hearing Loss in MCMV-infected Newborn Mice

Autori
Mijo Golemac, Đurđica Cekinović, Russell Bradford, Ester Pernjak Pugel, William J. Britt, Stipan Jonjić

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
2011 Annual Meeting of the Croatian Immunological Society ; Book of Abstracts / Polić, Bojan ; Grčević ; Danka(ur.). - Zagreb : Hrvatsko imunološko društvo, 2011

Skup
2011 Annual Meeting of the Croatian Immunological Society

Mjesto i datum
Rabac, Hrvatska, 07.10.2011. - 09.10.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
MCMV-infection; mice; sensorineural hearin loss

Sažetak
Human Cytomegalovirus (HCMV), as a leading infectious agent of neurological deficits in congenitally infected children, presents one of a major public health issue. It is estimated that up to 50% of symptomatic and 10% of asymptomatic children with congenital infection will develop sensorineural hearing loss (SNHL) (Dahle AJ et al. J Am Acad Audiol 2000). The mechanism of SNHL as a sequelae of viral infection is still undefined, and systemic viral burden in early infancy is shown to be the predictor of SHNL development in asymptomatic children (Ross S et al. Pediatr Infect Dis J 2009). Here we used our previously described model of perinatal mouse CMV (MCMV) infection of newborn mice to analyze the course of MCMV infection in inner ear and possible effect of the infection onto hearing processes in adult mice infected as newborns. The results showed that the cells in the newborn mouse cochlea are highly permissive for MCMV infection and virus presence in inner ear elicits robust inflammatory response. T lymphocytes were predominant immune cells present in inflammatory lesions in the inner ear of infected newborn mice. As a result neural cell densities in sprial ganglion of infected newborn mice was decreased as compared to controls and these mice had profound hearing loss at the adult age.

Izvorni jezik
Engleski

POVEZANOST RADA