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Pregled bibliografske jedinice broj: 552134

Bone morphogenetic protein (BMP)1-3 enhances bone repair

Grgurević, Lovorka; Maček, Boris; Merćep, Mladen; Jelić, Mislav; Smoljanović, Tomislav; Erjavec, Igor; Dumić-Čule, Ivo; Prgomet, Stefan; Đurđević, Dragan; Vnuk, Dražen et al.
Bone morphogenetic protein (BMP)1-3 enhances bone repair // Biochemical and biophysical research communications, 408 (2011), 1; 25-31 doi:10.1016/j.bbrc.2011.03.109 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 552134 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Bone morphogenetic protein (BMP)1-3 enhances bone repair

Autori
Grgurević, Lovorka ; Maček, Boris ; Merćep, Mladen ; Jelić, Mislav ; Smoljanović, Tomislav ; Erjavec, Igor ; Dumić-Čule, Ivo ; Prgomet, Stefan ; Đurđević, Dragan ; Vnuk, Dražen ; Lipar, Marija ; Stejskal, Marko ; Kufner, Vera ; Brkljačić, Jelena ; Matičić, Dražen ; Vukičević, Slobodan

Izvornik
Biochemical and biophysical research communications (0006-291X) 408 (2011), 1; 25-31

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BMP1-3; Bone fracture; ECM; BMP7; Differentiation

Sažetak
Members of the astacin family of metalloproteinases such as human bone morphogenetic protein 1 (BMP-1) regulate morphogenesis by processing precursors to mature functional extracellular matrix (ECM) proteins and several growth factors including TGFβ, BMP2, BMP4 and GFD8. We have recently discovered that BMP1-3 isoform of the Bmp-1 gene circulates in the human plasma and is significantly increased in patients with acute bone fracture. We hypothesized that circulating BMP1-3 might have an important role in bone repair and serve as a novel bone biomarker. When administered systemically to rats with a long bone fracture and locally to rabbits with a critical size defect of the ulna, recombinant human BMP1-3 enhanced bone healing. In contrast, neutralization of the endogenous BMP1-3 by a specific polyclonal antibody delayed the bone union. Invitro BMP1-3 increased the expression of collagen type I and osteocalcin in MC3T3-E1 osteoblast like cells, and enhanced the formation of mineralized bone nodules from bone marrow mesenchymal stem cells. We suggest that BMP1-3 is a novel systemic regulator of bone repair.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Veterinarska medicina



POVEZANOST RADA

Projekti:
108-1080327-0320 - Uloga TSH u modelu osteoporoze i u bolesnica sa smanjenom koštanom masom (Vukičević, Slobodan, MZOS ) ( CroRIS)

Ustanove:
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinika za traumatologiju

Profili:

Avatar Url Mladen Merćep (autor)

Avatar Url Jelena Brkljačić (autor)

Avatar Url Dragan Đurđević (autor)

Avatar Url Marija Lipar (autor)

Avatar Url Dražen Matičić (autor)

Avatar Url Dražen Vnuk (autor)

Avatar Url Slobodan Vukičević (autor)

Avatar Url Marko Stejskal (autor)

Avatar Url Vera Kufner (autor)

Avatar Url Mislav Jelić (autor)

Avatar Url Igor Erjavec (autor)

Avatar Url Ivo Dumić-Čule (autor)

Avatar Url Lovorka Grgurević (autor)

Avatar Url Tomislav Smoljanović (autor)

Poveznice na cjeloviti tekst rada:

doi ac.els-cdn.com www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Grgurević, Lovorka; Maček, Boris; Merćep, Mladen; Jelić, Mislav; Smoljanović, Tomislav; Erjavec, Igor; Dumić-Čule, Ivo; Prgomet, Stefan; Đurđević, Dragan; Vnuk, Dražen et al.
Bone morphogenetic protein (BMP)1-3 enhances bone repair // Biochemical and biophysical research communications, 408 (2011), 1; 25-31 doi:10.1016/j.bbrc.2011.03.109 (međunarodna recenzija, članak, znanstveni)
Grgurević, L., Maček, B., Merćep, M., Jelić, M., Smoljanović, T., Erjavec, I., Dumić-Čule, I., Prgomet, S., Đurđević, D. & Vnuk, D. (2011) Bone morphogenetic protein (BMP)1-3 enhances bone repair. Biochemical and biophysical research communications, 408 (1), 25-31 doi:10.1016/j.bbrc.2011.03.109.
@article{article, author = {Grgurevi\'{c}, Lovorka and Ma\v{c}ek, Boris and Mer\'{c}ep, Mladen and Jeli\'{c}, Mislav and Smoljanovi\'{c}, Tomislav and Erjavec, Igor and Dumi\'{c}-\v{C}ule, Ivo and Prgomet, Stefan and \DJur\djevi\'{c}, Dragan and Vnuk, Dra\v{z}en and Lipar, Marija and Stejskal, Marko and Kufner, Vera and Brklja\v{c}i\'{c}, Jelena and Mati\v{c}i\'{c}, Dra\v{z}en and Vuki\v{c}evi\'{c}, Slobodan}, year = {2011}, pages = {25-31}, DOI = {10.1016/j.bbrc.2011.03.109}, keywords = {BMP1-3, Bone fracture, ECM, BMP7, Differentiation}, journal = {Biochemical and biophysical research communications}, doi = {10.1016/j.bbrc.2011.03.109}, volume = {408}, number = {1}, issn = {0006-291X}, title = {Bone morphogenetic protein (BMP)1-3 enhances bone repair}, keyword = {BMP1-3, Bone fracture, ECM, BMP7, Differentiation} }
@article{article, author = {Grgurevi\'{c}, Lovorka and Ma\v{c}ek, Boris and Mer\'{c}ep, Mladen and Jeli\'{c}, Mislav and Smoljanovi\'{c}, Tomislav and Erjavec, Igor and Dumi\'{c}-\v{C}ule, Ivo and Prgomet, Stefan and \DJur\djevi\'{c}, Dragan and Vnuk, Dra\v{z}en and Lipar, Marija and Stejskal, Marko and Kufner, Vera and Brklja\v{c}i\'{c}, Jelena and Mati\v{c}i\'{c}, Dra\v{z}en and Vuki\v{c}evi\'{c}, Slobodan}, year = {2011}, pages = {25-31}, DOI = {10.1016/j.bbrc.2011.03.109}, keywords = {BMP1-3, Bone fracture, ECM, BMP7, Differentiation}, journal = {Biochemical and biophysical research communications}, doi = {10.1016/j.bbrc.2011.03.109}, volume = {408}, number = {1}, issn = {0006-291X}, title = {Bone morphogenetic protein (BMP)1-3 enhances bone repair}, keyword = {BMP1-3, Bone fracture, ECM, BMP7, Differentiation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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