Naslov
Biomarkers of inflammation in patients with angiographically assessed peripheral arterial disease

Autori
Perkov, Sonja ; Kardum Paro, Mirjana Mariana ; Šiftar, Zoran ; Grga, Ante ; Vidjak, Vinko ; Novačić, Karlo ; Flegar-Meštrić, Zlata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
First European Joint Congress of EFCC and UEMS / - , 2010

Skup
First European Joint Congress of EFCC and UEMS

Mjesto i datum
Lisabon, Portugal, 13.10.2010. - 16.10.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
biomarkers of inflammation; peripheral arterial disease

Sažetak
The purpose of this work was to present the new biomarkers of inflammation in patients with angiographically assessed peripheral arterial disease.According to the oxidation hypothesis of atherosclerotic diseases, oxidative damage is involved in the early development of atherosclerosis. Recently, HDL associated paraoxonase has been shown to inhibit the oxidative modification of LDL. The decreased PON1 concentration and activity in the plasma (PON1 status) in patients with atherosclerosis disease may cause decreased HDL antioxidant capacity and therefore significantly influence the risk of the development of atherosclerosis. There are a number of polymorphisms in the PON1 gene which affect PON1 activity and concentration. Recent studies have suggested that these polymorphisms may be a risk factor for development of atherosclerosis but it is not clear whether genotype or phenotype is most accuratly associated with risk of disease development. Another lipoprotein-associated enzyme, the platelet-activating factor acetylhydrolase (PAF-AH) catalyses the degradation of platelet activating factor and oxidatively fragmented phospholipids with potent biological activities and seems to have an antiatherogenic role. Plasma PAF-AH activity varies over approximately a fivefold range among patients and it is possible that polymorphisms in the PAF-AH gene are associated with differing susceptibility to atherosclerosis. According to the hypothesis that immune mechanisms play a key role in the development of atherosclerosis, oxidized LDL may be a key antigen in the atherosclerosis development (5). There are in vitro studies suggesting that antibodies to oxidized LDL may have an atherogenic effect by enhancing the lipid accumulation in macrophages in atherosclerotic vessels. Increased titer of oxidized LDL auto- antibodies in serum is considered predictive of atherosclerosis progression in subjects with a high lipid level.According to the hypothesis that atherosclerosis is a chronic inflammatory disease, the multiple lipoprotein-associated proteins that change in concentration during acute and chronic inflammation may serve as biochemical markers of the atherosclerotic process.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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