Naslov
Pentadecapeptide BPC 157 attenuates gastric lesions induced by alloxan in rats and mice

Autori
Petek, Marijan ; Sikirić, Predrag ; Anić, Tomislav ; Buljat, Gojko ; Šeparović, Jadranka ; Stančić-Rokotov, Dinko ; Seiwerth, Sven ; Grabarević, Željko ; Ručman, Rudolf ; Mikuš, Darko ; Zoričić, Ivan ; Prkačin, Ingrid ; Šebečić, Božidra ; Žiger, T. ; Čorić, Velimir ; Turković, Branko ; Aralica, Gorana ; Rotkvić, Ivo ; Miše, Stjepan ; Hahn, V.

Izvornik
Journal of Physiology-Paris (0928-4257) 93 (1999), 6; 501-4

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Pentadecapeptide BPC 157; Gastric lesions induced by alloxan; Alloxan; Rats; Mice

Sažetak
A diabetogenic alloxan regimen produced lesions in all stomachs of treated animals, either rats (200 mg x kg(-1) s.c.) or mice (400 mg x kg(-1) i.p.). In control animals, the lesions, when developed (i.e. 24 h following application), appear to be quite sustained, and consistently present also after 1 or 2 weeks. The application of the pentadecapeptide BPC 157 (10 microg or 10 ng x kg(-1) i.p. coadministered together with alloxan) would significantly attenuate these lesions' appearance. This beneficial effect seems to be present in either rats or mice and in either of the tested intervals. Importantly, the beneficial effect seems to be shared by both microgram and nanogram regimens.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA