Pregled bibliografske jedinice broj: 550243
Real-time expression of hTERT in primary melanoma biopsies
Real-time expression of hTERT in primary melanoma biopsies // Collegium antropologicum, 34 (2010), 4; 1401-1404 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 550243 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Real-time expression of hTERT in primary melanoma biopsies
Autori
Katunarić, Miljenko ; Jurišić, Davor ; Hadžisejdić, Ita ; Kirin, Ivan ; Zamolo, Gordana
Izvornik
Collegium antropologicum (0350-6134) 34
(2010), 4;
1401-1404
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
hTERT; primary melanoma; Real-Time; expression; biopsies
Sažetak
Skin melanoma is by far the most lethal skin cancer, it is unpredictable by nature and presents a severe diagnostic problem. One of the major issues in melanoma diagnostics is to differentiate it with confidence from a dysplastic nevus. Thus, the aim of this study was to evaluate hTERT expression on a spectrum of dermal lesions (from normal skin to primary melanoma) in order to examine its possible role as a diagnostic marker in melanoma diagnostics. In this study we analyzed the expression of hTERT by real-time PCR on 58 freshly obtained biopsy samples (4 samples of normal skin, 12 dermal nevi, 23 dysplastic nevi, 19 primary melanomas). Our results showed slightly greater hTERT expression in dysplastic nevi than melanomas with major data overlap. Considering the given results, hTERT does not seem to be a reliable diagnostic marker for melanoma.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
062-0000000-3545 - Telomerazna aktivnost i imunofenotipske karakteristike limfocita u melanomu kože (Zamolo, Gordana, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Gordana Zamolo
(autor)
Davor Jurišić
(autor)
Ita Hadžisejdić
(autor)
Miljenko Katunarić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Social Science Citation Index (SSCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE