Naslov
Prognostic value of MAGE-A and NY-ESO-1 expression in pharyngeal cancer

Autori
Pastorčić-Grgić, Marija ; Šarčević, Božena ; Došen, Danijel ; Juretić, Antonio ; Spagnoli, Giulio G. ; Grgić, Marko

Izvornik
Head and neck-journal for the sciences and specialties of the head and neck (1043-3074) 32 (2010), 9; 1178-1184

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Pharyngeal cancer; MAGE-A; NY-ESO-1

Sažetak
Background. The prognostic value of cancer testis antigens in pharyngeal cancer is understudied. Methods. We recruited 90 patients who were treated for pharyngeal cancer. Monoclonal antibodies 57B and B9.8.1.1 were used for detection of MAGE-A and NY-ESO-1 genes. Results. MAGE-A and NY-ESO-1 gene products were detectable in 70.0% and 33.3% of pharyngeal tumors, respectively. No correlation was established between MAGE-A and NY-ESO-1 expression and TNM staging at presentation. Survival analysis showed a trend toward a shorter 5-year disease free survival in the group of patients with MAGE-A–positive tumors (log-rank test, p ¼ .122). In contrast, a trend toward a prolonged 5-year disease-free survival was observed in the group of patients with NY-ESO-1–positive tumors (log-rank test, p ¼ .219). Conclusion. In a large population of patients with pharyngeal cancer and available 5-year survival data, prognosis tended to be poorer with MAGE-A expression and better with NY-ESO-1 expression, but the correlations did not reach statistical significance.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Rad je kalo poster prezentiran na skupu 22nd European Congress of Pathology, održanom od 04.-09. 2009., Firenca, Italija ; sazetak je uz međunarodnu recenziju objavljen u Virchows Archiv 455(1) ; str. S339-S339 ; ISSN 0945-6317.

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