Naslov
Neurological Evaluation of Growth-Restricted Fetuses

Autori
Salihagić Kadić, Aida

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 10th World Congress of Perinatal Medicine 2011 ; u: Journal of perinatal medicine 39 (2011) (S1) ; Oral and Poster Abstracts Presentation / Dudenhausen, Joachim W. - , 2011, 213-214

Skup
World Congress of Perinatal Medicine (10 ; 2011)

Mjesto i datum
Punta del Este, Urugvaj, 08.11.2011. - 11.11.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
IUGR; hypoxia; fetal doppler; four dimensional ultrasound; brain development

Sažetak
Intrauterine growth restriction (IUGR) and fetal hypoxia are risk factors for the development of the central nervous system (CNS) disorders. Fetal cardiovascular responses to hypoxia, which include the redistribution of the cardiac output towards the vital organs, are considered the most important adaptive reactions responsible for maintaining fetal homeostasis. The redistribution of blood flow towards the fetal brain is known as the brain-sparing effect. Our studies have demonstrated clearly that the brain- sparing effect cannot prevent the development of perinatal brain damage in the case of severe or prolonged hypoxia. Further, we have showed that hypoxia index, which takes into account cumulative oxygen deficit, could significantly improve the prediction of a poor neurological outcome in pregnancies complicated by IUGR and hypoxia. However, there is currently no direct method in the routine practice for assessment of the fetal CNS, although it is believed that fetal behavior reflects the brain development. After standardization of valid reference ranges of movements appropriate for the gestational age, a new scoring system for fetal behavior based on prenatal assessment by four dimensional (4D)sonography, KANET, was published. Further, we studied behavior of the severe growthrestricted fetuses using KANET and assessed its relationship with the hemodynamic parameters. In this case study abnormal fetal behavior correlated with pathologic hemodynamic parameters and with adverse postnatal outcome. However, not all fetuses with abnormal hemodynamic findings have pathological behavior. In recently published case report, we presented prenatal and postnatal neurological evaluation of the fetus and newborn from pregnancy complicated with IUGR, fetal hypoxemia, and preterm labor. Despite unfavorable intrauterine conditions, this infant showed normal early neurological development. Further studies involving a larger sample size are needed to ascertain the role of KANET and 4D ultrasound in the evaluation of neurological development of growth-restricted fetuses.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA