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Pregled bibliografske jedinice broj: 547601

The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes

Sakaguchi, S.; Hombauer, M.; Bilić, Ivan; Naoe, Y.; Schebesta, A.; Taniuchi, I.; Ellmeier, W.
The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes // Nature immunology, 11 (2010), 5; 442-448 doi:10.1038/ni.1860 (međunarodna recenzija, članak, znanstveni)

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Naslov
The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes

Autori
Sakaguchi, S. ; Hombauer, M. ; Bilić, Ivan ; Naoe, Y. ; Schebesta, A. ; Taniuchi, I. ; Ellmeier, W.

Izvornik
Nature immunology (1529-2908) 11 (2010), 5; 442-448

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CD8 antigen; transcription factor; transcription factor MAZR; zinc finger protein

Sažetak
The CD4 versus CD8 lineage specification of thymocytes is linked to coreceptor expression. The transcription factor MAZR has been identified as an important regulator of Cd8 expression. Here we show that variegated CD8 expression by loss of Cd8 enhancers was reverted in MAZR-deficient mice, which confirms that MAZR negatively regulates the Cd8 loci during the transition to the double-positive (DP) stage. Moreover, loss of MAZR led to partial redirection of major histocompatibility complex (MHC) class I-restricted thymocytes into CD4 + helper-like T cells, which correlated with derepression of Th-POK, a central transcription factor for helper-lineage development. MAZR bound the silencer of the gene encoding Th-POK, which indicated direct regulation of this locus by MAZR. Thus, MAZR is part of the transcription factor network that regulates the CD8 lineage differentiation of DP thymocytes.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
098-0982913-2332 - Molekularne interakcije u diferencijaciji limfocita (Antica, Mariastefania, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Ivan Bilić (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Sakaguchi, S.; Hombauer, M.; Bilić, Ivan; Naoe, Y.; Schebesta, A.; Taniuchi, I.; Ellmeier, W.
The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes // Nature immunology, 11 (2010), 5; 442-448 doi:10.1038/ni.1860 (međunarodna recenzija, članak, znanstveni)
Sakaguchi, S., Hombauer, M., Bilić, I., Naoe, Y., Schebesta, A., Taniuchi, I. & Ellmeier, W. (2010) The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes. Nature immunology, 11 (5), 442-448 doi:10.1038/ni.1860.
@article{article, author = {Sakaguchi, S. and Hombauer, M. and Bili\'{c}, Ivan and Naoe, Y. and Schebesta, A. and Taniuchi, I. and Ellmeier, W.}, year = {2010}, pages = {442-448}, DOI = {10.1038/ni.1860}, keywords = {CD8 antigen, transcription factor, transcription factor MAZR, zinc finger protein}, journal = {Nature immunology}, doi = {10.1038/ni.1860}, volume = {11}, number = {5}, issn = {1529-2908}, title = {The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes}, keyword = {CD8 antigen, transcription factor, transcription factor MAZR, zinc finger protein} }
@article{article, author = {Sakaguchi, S. and Hombauer, M. and Bili\'{c}, Ivan and Naoe, Y. and Schebesta, A. and Taniuchi, I. and Ellmeier, W.}, year = {2010}, pages = {442-448}, DOI = {10.1038/ni.1860}, keywords = {CD8 antigen, transcription factor, transcription factor MAZR, zinc finger protein}, journal = {Nature immunology}, doi = {10.1038/ni.1860}, volume = {11}, number = {5}, issn = {1529-2908}, title = {The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes}, keyword = {CD8 antigen, transcription factor, transcription factor MAZR, zinc finger protein} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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