Naslov
Interaction of Genetic Risk Factors Confers Increased Risk for Metabolic Syndrome : The Role of Peroxisome Proliferator-Activated Receptor γ

Autori
Božina, Tamara ; Sertić, Jadranka ; Lovrić, Jasna ; Jelaković, Bojan ; Šimić, Iveta ; Reiner, Željko

Izvornik
Genetic Testing and Molecular Biomarkers (1945-0265) 18 (2014), 1; 32-40

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
metabolic syndrome; genetic polymorphisms; peroxisome proliferator-activated receptor γ gene; lipoprotein lipase; interleukin 6; angiotensin converting enzyme; angiotensin II type 1 receptor

Sažetak
The aim of the study was to estimate the influence of interactions between PPARγ and target genes LPL, IL6, ACE and AT1R on metabolic syndrome (MetSy) and its traits. Methods: Study included 527 participants (263 with MetSy and 264 controls). Genotyping of PPARγ Pro12Ala, LPL PvuII (-/+), IL6 -174G>C, ACE I/D and AT1R 1166A>C was performed using PCR-RFLP based methods. Results: Interaction between PPARγ Pro12Ala and LPL (Pvu-/+) improved prediction of MetSy over and above prediction based on model containing no interactions (χ2=7.22 ; df=1 ; p=0.007). In the group of participants with PPARγ Pro12Ala or Ala12Ala genotypes, those with LPL Pvu (-/+) or (+/+) genotype had greater odds for MetSy (OR=5.98 ; 95% CI: 1.46-24.47, p=0.013). Interaction between PPARγ Pro12Ala and IL6 -174G>C improved prediction of high fasting blood glucose (χ2=13.99 ; df=1 ; p<0.001). PPARγ Ala12 variant was found protective in patients with IL6 -174GG genotype (OR=0.10 ; 95% CI: 0.02-0.57, p=0.01), while in the case of IL6 -174C allele carriers, for PPARγ Ala12 carriers larger odds for high glucose levels compared to Pro12 variant were observed (OR=2.39 ; 95% CI: 1.11-5.17, p=0.026). Interactions of PPARγ and ACE were significant for BMI. In the group with ACE DD genotype, those with PPARγ Pro12Ala or Ala12Ala genotype have greater odds for obesity (OR=9.98 ; 95% CI: 1.18-84.14, p=0.034). Conclusions: PPARγ gene variants can, in interaction with some of its target genes, modulate physiological processes leading to the development of MetSy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA