Naslov
Polymorphisms in 17q12-21 are associated with asthma exacerbation and lung function in asthmatic children

Autori
Blekić, Mario ; Kljaić Bukvić, Blaženka ; Aberle, Neda ; Marinho, Susana, Čustović, Adnan ; Simpson, Angela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Eur Respir J ; 38: Suppl. 55 / Anh Tuan Dinh-Xuan, Vito Brusasco - Sheffield, 2011

Skup
29st Annual Congress of European Respiratory Society

Mjesto i datum
Amsterdam, Nizozemska, 24.09.2011. - 28.09.2011

Vrsta sudjelovanja
Ostalo

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
17q region; lung function; smoke; childhood asthma

Sažetak
Background: More then 15 studies associated genetic variants in 17q21 region with asthma.We aimed to investigate whether amongst Croatian asthmatic children, genetic variants in this region are associated with asthma severity and exacerbation. Methods: We recruited 423 children aged 6-18 years with physician-diagnosed asthma. Information on hospital admission with asthma exacerbations was retrieved from medical records. Data on wheeze frequency and environmental tobacco smoke (ETS) exposure was collected using validated questionnaire. Lung function (FEV1%predicted) was measured using spirometry. We analyzed 35 haplotype-tagging SNPs in 17q21. Results: We found significant associations between 4 SNPs and hospital admissions (rs12150079, rs7212938, rs2290400, rs8067378). For example, G allele homozygotes in rs12150079 were at higher risk of being admitted to hospital than carriers of A allele (aOR 1.85, 95%CI 1.26-2.72, p=0.002) ; this SNP was also associated with current wheezing. Six SNPs were associated with lung function (rs9635726, rs921651, rs9900538, rs3169572, rs4795403, rs471692). In addition, we observed significant interaction between 3 SNPs (rs12603332, rs8067378, rs9303277) and in utero ETS exposure in relation to lung function (pint<0.04), in that amongst children of mothers who smoked during pregnancy, major allele homozygotes had lower FEV1%predicted than minor allele carriers, but amongst non-exposed children there was no difference in lung function between different genotype groups. Conclusion: Variants in 17q12-21 region may be associated with asthma severity and may interact with in utero ETS exposure in determining lung function amongst asthmatic children. 586s

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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