Naslov
Distribution and morphology of different GABAergic interneuron subpopulations in the human neocortex

Autori
Džaja, Domagoj ; Jovanov Milošević, Nataša ; Petanjek, Zdravko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
SINAPSA Neuroscience Conference ’11, Central European FENS Featured Regional Meeting, Ljubljana, Slovenia, September 22-25.09.2011. SINAPSA Abstract Book, pg. 91. / - , 2011

Skup
SINAPSA Neuroscience Conference ’11, Central European FENS Featured Regional Meeting.

Mjesto i datum
Ljubljana, Slovenija, 22.09.2011. - 25.09.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
interneurons; tangential migration; ganglionic eminence; upper subventricular zone; principal glutamatergic neurons; schizophrenia

Sažetak
Gamma-aminobutyric-acidergic (GABAergic) cells form a very heterogeneous population of neurons that play a crucial role in the coordination and integration of cortical functions. Dysfunction or cell death of several specific types has been described as a hallmark of various psychiatric and neurological disorders and it is suggested that organization of GABAergic network shows several features specific for primate neocortex. However, present data are limited and inconsistent, so our aim was to describe, in the human neocortex, distribution and morphology of cortical cells that stain for three main chemical subclasses of GABAergic neurons. Sections of human prefrontal cortex were immunochytochemically stained for parvalbumin (PV), calretinin (CR) and calbindin (CB). PV stained cells have highest density and were diffusely distributed through all cortical layers, frequently with extensive staining of processes. Sublayers of cells with heavy stained cell body were found in supragranular layers and large heavy stained cells were located in the deep part of layer VI. Vast majority of CR positive cells have heavy stained cell body and most of them were located in supragranular layers, only very sporadically in infragranular. Strongly labeled CB positive cells have formed a densely packed belt in the upper part of layer II and in the other layers, both supragranular and infragranular, they were diffusely distributed at lower density. Comparing our data with description in rodents and nonhuman primates, we concluded that organization of cortical GABA-ergic network changed highly through evolution and that even some subtle differences could be seen comparing human and rhesus monkey.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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