Naslov
Effects of oxime K203 and oxidative stress in plasma of tabun poisoned rats

Autori
Berend, Suzana ; Lucić Vrdoljak, Ana ; Musilek, Kamil ; Kuča, Kamil ; Radić, Božica

Izvornik
Croatica chemica acta (0011-1643) 85 (2012), 2; 193-199

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
tabun; therapy; K203; cholinesterase; lipid peroxidation; superoxide dismutase

Sažetak
The highly toxic nature of tabun has been known for many years, but there are still serious limitations to antidotal therapy. In this study, we used rats as an experimental model to evaluate the efficiency of bispyridinium para-oxime K203 as therapy against tabun poisoning as well as to examine if induction of oxidative stress is linked to organophosphate toxicity. K203 showed high potency in counteracting tabun poisoning. Either alone or in combination with atropine, this oxime significantly increased cholinesterase activity at 0.5 and 1 h compared to untreated rats poisoned with tabun. Simultaneous measurements of markers of oxidative stress (lipid peroxidation and superoxide dismutase) showed that tabun poisoning, but also therapy (oxime alone or oxime plus atropine) applied immediately after tabun poisoning, could generate free radical species that may cause oxidative stress in rats.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA