Naslov
Expression of Toll-llike receptor 4 and beta 1 integrin in breast cancer

Autori
Petričević, Branka ; Vrbanec, Damir ; Jakić Razumović, Jasminka ; Brčić, I. ; Rabić, Domagoj ; Badovinac, Tanja ; Ozimec, E. ; Bali, V.

Izvornik
Medical oncology (1357-0560) 29 (2011), 2; 486-494

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
breast cancer; Toll-llike receptor 4; Integrin beta1

Sažetak
Toll-like receptor (TLR) 4 signaling pathway has been shown to support tumor cell growth in vitro and in vivo. Its stimulation on breast cancer cell lines induces β1 integrin and promotes tumor invasiveness. However, its role in predicting clinical behavior of tumor is not yet clarified. Therefore, we investigated TLR4 and β1 integrin expression on 133 primary breast cancer samples by immunohistochemistry and correlated it with overall survival and disease-free survival of patients as well as with clinicopathological characteristics of the tumor. We found higher β1 integrin expression in invasive lobular cancer in comparison with other tumor types. No significant association of TLR4 and β1 integrin expression with overall survival or disease-free survival was seen. Therefore, we conclude that expression of these markers is of biological interest but appears to be of little additional use as predictive clinical marker.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA