Naslov
Role of H. pylori eradication therapy success on five year dynamics of dysplasia

Autori
Filipec Kanizaj, Tajana ; Katicic, Miroslava ; Skurla, Bruno ; Prskalo, Marija ; Colic Cvrlje, Vesna ; Naumovski Mihalic, Slavica ; Mrzljak, Anna ; Bradic, Tihomir ; Sobocan, Nikola

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Helicobacter, 16, Suppl 1 / David Y Graham - Cambridge : John Wiley & Sons, 2011, 80-80

Skup
24 International Workshop on Helicobacter and Related Bacteria in Chronic Digestive Inflammation and Gastric Cancer

Mjesto i datum
Dublin, Irska, 11.09.2011. - 13.09.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
dysplasia; eradication therapy; H. pylori

Sažetak
Aim: to investigate the role of eradication therapy success on five year dynamics of dysplasia. Materials and methods: study was performed on 41 H. pylori positive patients with dysplasia in basic bioptic specimens analyzed according to updated Sydney protocol. All patients received triple eradication therapy. Therapy success and dynamics of dysplasia were evaluated according to 5th year histological finding. Results: basically 41 patients had dysplasia in corpus and/or antrum. Grade I 7, 31%, grade II 39, 02% and grade III 53, 65% of patients. H. pylori was successfully eradicated in 37 patients (90, 24%). In successfully eradicated, complete regression of dysplastic changes appeared in 33/37 (90, 89%) of patients. In all of rest 3 eradicated patients regression of grade of dysplasia was observed. In 2 of 4 non- eradicated patients complete regression of dysplasia and for rest 2 only regression of grade of dysplasia appeared. Statistically significant dynamics of grade of dysplasia was observed for successfully eradicated patients (Wilcox rank sum test, p<0, 001). The difference in proportion of patients with complete regression of dysplasia between eradicated and non - eradicated is statistically significant. Conclusions: In five year interval, proportion of patents with complete regression of dysplasia is statistically significantly higher in successfully eradicated patients than non- eradicated. In both groups regression of grade of dysplasia (and no progression) was observed with application of eradication therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA