Naslov
The paraoxonase 1, paraoxonase 2 and paraoxonase 3 in humans

Autori
Grdić Rajković, Marija ; Barišić, Karmela ; Rumora, Lada

Izvornik
Biocmemia Medica (1330-0962) 21 (2011); 122-130

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
paraoxonase 1; paraoxonase 2; paraoxonase 3

Sažetak
The paraoxonase gene family in humans includes three members: pon1, pon2 and pon3. The products of those three genes are the following enzymes: paraoxonase 1 (PON1), paraoxonase 2 (PON2) and paraoxonase 3 (PON3). PON1 is mainly associated with a high density lipoprotein (HDL). A small amount of this enzyme is also bound to very low-density lipoprotein (VLDL) and postprandial chylomicrons. PON1 posses organophosphatase, arylesterase and lactonase activity and it hydrolyzes many different substrates. It is also known that PON1 may have antiatherogenic function. Compared to the PON1, PON2 and PON3 are much less studied and described. PON2 is ubiquitously expressed intracellular protein, while PON3 is bounded to HDL, like PON1. The both enzymes posses antioxidant properties.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA