Pregled bibliografske jedinice broj: 542138
Prognostic significance of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1) in patients with primary invasive ductal breast carcinoma - a 7.5-year follow-up study.
Prognostic significance of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1) in patients with primary invasive ductal breast carcinoma - a 7.5-year follow-up study. // Tumori, 97 (2011), 4; 532-539 doi:10.1700/950.10409 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 542138 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Prognostic significance of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1) in patients with primary invasive ductal breast carcinoma - a 7.5-year follow-up study.
Autori
Jelisavac-Čosić, Sanda ; Sirotković-Skerlev, Maja ; Kulić, Ana ; Jakić-Razumović, Jasna ; Kovač, Zdenko ; Vrbanec, Damir
Izvornik
Tumori (0300-8916) 97
(2011), 4;
532-539
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
uPA ; PAI-1 ; breast cancer
Sažetak
Urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1) are key molecules in pericellular proteolysis, a process that plays an important role in tumor invasion and metastasis. In the current study we investigated the prognostic significance of uPA and PAI-1 in primary invasive breast cancer. uPA and PAI-1 antigen levels were determined by enzyme-linked immunosorbent assay in cytosols of 177 invasive ductal carcinoma specimens. The prognostic significance of uPA and PAI-1 was assessed for overall survival. The median follow-up time was 90 months. In univariate analysis, both uPA (third versus first tertile range of values ; P = 0.02 ; HR = 2.08) and PAI-1 (third versus first tertile ; P = 0.0007 ; HR = 3.1) were significant prognostic markers for overall survival. In multivariate analysis only nodal status (N2 vs N0 ; P = 0.0001 ; HR = 3.94) and PAI-1 (third versus first tertile ; P = 0.004 ; HR = 3.05) remained significant independent prognostic factors. Both uPA and PAI-1 were correlated with established prognostic markers including histological grade, tumor size and Nottingham index. Our study with a 7.5-year follow-up confirmed the relation between elevated uPA and PAI-1 values and an aggressive course of invasive breast cancer. The prognostic significance of PAI-1 as an independent marker was proved for the overall group of breast cancer patients and the subgroup of node-positive patients.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
098-0982464-2508 - Molekularna genetika i farmakogenetika gastrointestinalnih tumora (Kapitanović, Sanja, MZOS ) ( CroRIS)
108-0000000-2063 - Patofiziologija sepse u splenektomiranim i normospleničnim miševima (Kovačić, Zdenko, MZOS ) ( CroRIS)
108-1080058-0046 - KARCINOM DOJKE-MOLEKULARNE,GENETSKE I KLINIČKE KARAKTERISTIKE (Vrbanec, Damir, MZOS ) ( CroRIS)
108-1080058-0047 - Molekularni biljezi u solidnim tumorima - prediktivni i prognostički značaj (Pleština, Stjepko, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
