Naslov
Angiotensin-converting enzyme (ACE) I/D gene polymorphism in multiple sclerosis

Autori
Stanković, Aleksandra ; Gašparović, Iva ; Peterlin, Borut ; Klupka-Sarić, Inge ; Živković, Maja ; Starčević Čizmarević, Nada ; Lovrečić, Luca ; Sinanović, Osman ; Dinčić, Evica ; Perković, Olivio ; Rudolf, Gorazd ; Vidović, Mirjana ; Stojković, Ljiljana ; Lavtar, Polona ; Sehanović, Aida ; Ristić, Smiljana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Multiple Sclerosis Journal, Supplement / Thompson, Alan J - , 2011, S115-S115

Skup
5th Joint triennial Congress of the European and Americas Committees For Treatment and Research in Multiple Sclerosis (ECTRIMS)

Mjesto i datum
Amsterdam, Nizozemska, 19.10.2011. - 22.10.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ACE I/D; gene polymorphism; multiple sclerosis; susceptibility gene

Sažetak
Background and goals: Increased angiotensin-converting enzyme (ACE) activity in the blood and cerebrospinal fluid of MS patients and the suppression of disease development in experimental autoimmune encephalomyelitis after ACE blockade suggest that ACE may play a role in the pathogenesis of MS. Serum levels of ACE are modulated by an insertion/deletion (I/D) polymorphism in intron 16 of the ACE gene. The aim of this study was to investigate the possible influence of the ACE I/D polymorphism on MS susceptibility in Croatian, Slovenian, Serbian, and Bosnian and Herzegovinian populations that share the same geographic location and have a similar ethnic background of Slavic origin. Materials and Methods: The study included a total of 867 patients (588 female, 279 male) who fulfilled McDonald’s criteria for MS. The control group consisted of 851 healthy, unrelated, ethnically matched blood donors who had no family history of MS or any other inflammatory-demyelinating disease. The ACE I/D polymorphism was genotyped by polymerase chain reaction. Results: Allele and genotype frequencies of pooled MS patients and controls were not significantly different (P > 0.05). When MS patients were stratified by gender and disease course, no significant differences (P > 0.05) in genotype distribution were observed. Meta-analysis revealed that the ACE DD genotype does not increase the risk for MS (OR = 1.08, 95% CI 0.88 – 1.33, z = 0.741, P = 0.459, Pheterogeneity = 0.814). Conclusion: Our results indicate that the ACE I/D polymorphism overall does not contribute to MS susceptibility in the Slavic populations investigated.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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