Naslov
CTLA-4 +49 A/G gene polymorphism in Croatian and Slovenian multiple sclerosis patients

Autori
Starčević Čizmarević, Nada ; Gašparović, Iva ; Peterlin, Borut ; Sepčić, Juraj ; Rudolf, Gorazd ; Kapović, Miljenko ; Lavtar, Polona ; Ristić, Smiljana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The Seventh ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine ; Final Program and Abstracts / Schanfield, Moses ; Primorac, Dragan ; Vuk-Pavlović, Stanimir - Zagreb : International Society for Applied Biological Sciences (ISABS), 2011, 273-273

Skup
Peti hrvatski kongres iz humane genetke

Mjesto i datum
Bol, otok Brač, Hrvatska, 20.06.2011. - 21.06.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Multiple sclerosis; cytotoxic T lymphocyte antigen 4; gene; polymorphism; association studies

Sažetak
Polymorphisms in the CTLA-4 gene are known to be important in several autoimmune diseases, including multiple sclerosis (MS). Previous studies on the impact of CTLA-4 +49 A/G gene polymorphism have given contradictory results. We investigated the possible influence of this polymorphism on MS susceptibility and disease behavior in Croatian and Slovenian populations. Genotyping was performed in 367 MS patients and 480 control subjects using PCR-RFLP method. The G allele was present in 216 (58.9%) MS patients vs. 282 (58.7%) healthy controls (p = 0.975, OR = 1.01, 95% CI = 0.76-1.32). No significant differences were observed in CTLA-4 +49 A or G allele distribution between patients and controls, indicating that this polymorphism does not influence susceptibility to MS in the surveyed populations. No correlation was observed between G allele carrier status and age at disease onset, disease course, or severity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA