Naslov
Biomimetic study of the resulting effect of oxidative free radical conditions in lipids

Autori
Mihaljević, Branka ; Tartaro-Bujak, Ivana ; Ferreri, Carla ; Chatgilialoglu, Chryssostomos

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts/COST Chemistry CM0603 Scientific Meeting, Radical Stress and Defenses / Ozben, Tomris - Istanbul : Bogazici University, 2010, 23-23

Skup
Radical Stress and Defenses

Mjesto i datum
Istanbul, Turska, 02.12.2010. - 03.12.2010

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
Lipidomic; Lipid isomerization; Lipid peroxidation; Model

Sažetak
The far most known process regarding polyunsaturated fatty acids (PUFA) is the peroxidation process which is generally considered to be the major mechanism of cell injury in organisms subject to oxidative stress. A much recent research deals with the geometrical isomerization of PUFA, evidencing that the cis double bond configuration is a inherent characteristic of membrane lipids which can be altered by radical stress. In view of the fact that these processes in lipids are the most relevant chemical processes occurring to PUFAs, it is very useful to perform model studies where both processes occur. Lipid reactivity can be addressed by biomimetic chemistry. We have established the simplest biomimetic model of cell membrane, the mixed nonionic/anionic surfactant micelles of linoleic acid. The irradiation-induced peroxidation and trans isomerization in our model systems under controlled oxidation conditions have been studied. Data on relative importance of these processes in this competitive environment have been considered. This lecture will demonstrate that hydroperoxy- and trans-PUFA can be the resulting effect of oxidative free radical conditions.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA