Naslov
The evolutionary origin of orphan genes

Autori
Diethard, Tautz ; Domazet-Lošo, Tomislav

Izvornik
Nature reviews genetics (1471-0056) 12 (2011), 10; 692-702

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
lineage-specific genes; protein evolution; eukaryotic evolution; inverse relationship; mammalian genes; expressed genes; genomic orfans; noncoding dna; evo-devo; drosophila

Sažetak
Gene evolution has long been thought to be primarily driven by duplication and rearrangement mechanisms. However, every evolutionary lineage harbours orphan genes that lack homologues in other lineages and whose evolutionary origin is only poorly understood. Orphan genes might arise from duplication and rearrangement processes followed by fast divergence ; however, de novo evolution out of non-coding genomic regions is emerging as an important additional mechanism. This process appears to provide raw material continuously for the evolution of new gene functions, which can become relevant for lineage-specific adaptations.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA