Naslov
Level of vascular endothelial growth factor in recurrent aphthous ulceration

Autori
Brozović-Sistig, Suzana ; Vučićević-Boras, Vanja ; Kleinheinz, Josef ; Joos, Uli ; Jukić, Silvana

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
IADR CED/NEF / Academia Medica Varsoviensis - Varšava : Academia Medica Varsoviensis, 2000

Skup
The 4th Joint Meeting of the IADR CED/Nof

Mjesto i datum
Varšava, Poljska, 24.08.2000. - 27.08.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
vascular endothelial factor; aphthous ulcers

Sažetak
Saliva contains biologically active proteins such as several different growth factors, cytokines and prostaglandins. This study investigated salivary level of vascular endothelial growth factor in 30 patients with minor and major recurrent aphthous ulceration (RAU) and 27 age matched healthy controls. VEGF was determined by ELISA in resting whole saliva of all participants. The development of recurrent aphthous ulceration was divided into stages: (1) early prodromal stage (mucosal redness or erosion), (2) active disease (frank ulceration) and (3) remission stage. Significantly lower level of salivary VEGF (p<0,001) was found in patients with major RAU during active disease when compared to the controls. Statistical analysis was done by Student t test. The mean ąSD were 327, 02ą113,05 pg/ml in acute stage of major RAU and 1488,88ą605,38 pg/ml in healthy controls. Salivary VEGF showed stage dependent alterations as well as variations regarding the type of ulcers. The VEGF concentration decreased significantly during the active stage of a disease and increased during the remission period in patients with major RAU. No differences in salivary VEGF in patients with acute minor RAU as well as during remission period when compared to controls was found. In conclusion, diminution of salivary VEGF was observed in acute stage of major RAU suggesting active involvement of this compound in the pathogenesis of the disease. It is also suggested that VEGF may also have cytoprotective role in homeostasis of oral cavity.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

POVEZANOST RADA