Pregled bibliografske jedinice broj: 537148
Heart rate variability during and after acute intermittent hypoxia in rats
Heart rate variability during and after acute intermittent hypoxia in rats // International Brain Research Organisation
Firenca, Italija, 2011. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 537148 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Heart rate variability during and after acute intermittent hypoxia in rats
Autori
Valic, Maja ; Valic, Zoran ; Pavlinac, Ivana ; Pecotic Renata ; Đogaš, Zoran
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
International Brain Research Organisation
/ - , 2011
Skup
IBRO World Congress of Neuroscience
Mjesto i datum
Firenca, Italija, 14.06.2011. - 18.06.2011
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
intermittent hypoxia; heart rate; rats
Sažetak
Stimulation of breathing with acute intermittent hypoxia (AIH) elicits increases in respiratory and sympathetic outflow. Previous studies have shown that AIH produces increases in respiratory and sympathetic nerve activity that last long after hypoxic stimulation have ceased. Variability of heart rate (HR) from ECG recordings has been used as a non-invasive measure of cardiac autonomic modulation. This study was performed to investigate the HR variability in urethane-anesthetized, mechanically ventilated Sprague-Dawley rats exposed to five 3 minutes hypoxias. Blood pressure and ECG was monitored throughout the experiment and analyzed in the period during hypoxic exposures, 15, 30 and 60 minutes after the last hypoxic episode. Mean RR interval was 156.25 ms during baseline and did not significantly change throughout the experiment (151.72 ; 160.43 ; 161.91 and 157.77 ms, P=0.17). Low frequency (LF) component increased from 0.65 nu prior to hypoxia to 1.06 nu during the first hypoxic exposure and to 3.62 ; 9.46 and 1.79 nu at 15, 30 and 60 minutes after the last hypoxic episode, respectively (P=0.043). LF/HF ratio increased from 0.5 to 2.64 during the first hypoxic exposure and to 2.72 ; 6.15 and 6.9 nu at 15, 30 and 60 minutes after the last hypoxic episode, respectively (P=0.043). In time control experiments no change in HR variability was noted during the same time period observed. Conclusion: Heart rate variability shows significant changes during and after AIH protocol indicating the increase in sympathetic modulation of cardiac function during hypoxia and at the time after hypoxic exposures.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
216-2163166-0513 - Neuralna kontrola disanja u budnosti i spavanju (Đogaš, Zoran, MZOS ) ( CroRIS)
216-2163166-3342 - Središnja regulacija kardiovaskularnog i respiracijskog sustava-uloga serotonina (Valić, Maja, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Split
Profili:
Zoran Valić
(autor)
Renata Pecotić
(autor)
Maja Valić
(autor)
Zoran Đogaš
(autor)
Ivana Pavlinac Dodig
(autor)