Naslov
Histopathological evaluation and immunohistochemical study of estrogen receptor α, HER-2 and Ki-67 in canine neoplastic mammary lesions

Autori
Gudan Kurilj, Andrea ; Hohšteter, Marko ; Artuković, Branka ; Severin, Krešimir ; Šoštarić-Zuckermann, Ivan-Conrado ; Beck, Ana ; Seiwerth, Sven ; Sabočanec, Ruža ; Grabarević, Željko

Izvornik
Veterinarski arhiv. (0372-5480) 81 (2011), 6; 709-722

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
mammary tumors; dog; ERα; HER-2; Ki-67

Sažetak
The frequence of different types of mammary lesions and their relationship with histologic grade was investigated. 146 mammary lesions were classified according to World Health Organisation (WHO) criteria. Selected lesions (51 malignant and 24 benign) were investigated to determine the immunohistochemical expression of estrogen receptor alpha (ERα), HER-2 and Ki-67 and their relationship with tumor factors. The most common breeds affected were cross breeds, poodles, cocker spaniels and German shepherds and the median age of tumor diagnosis was 10 years (range 4 – 15 years of age). Classification of all canine mammary gland lesions revealed 110 (75.3%) malignant and 36 (24.7%) benign tumors. ERα was expressed by 9/24 (37.5%) benign and 9/51 (17.6%) malignant tumors. HER-2 protein was detected in 5/51 (9.8%) malignant tumors but none of 24 benign tumors. The Ki-67 index was higher in malignant (mean 29.5) than benign (mean 9.1) tumors (P< 0.001) and significantly higher in anaplastic carcinomas than tubulopapillary carcinomas (P< 0.05)

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA