Pregled bibliografske jedinice broj: 536314
Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT(1A) receptor in the caudal raphe region of the rat
Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT(1A) receptor in the caudal raphe region of the rat // Journal of sleep research, 21 (2012), 2; 195-203 doi:10.1111/j.1365-2869.2011.00948.x (međunarodna recenzija, članak, znanstveni)
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Naslov
Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT(1A) receptor in the caudal raphe region of the rat
Autori
Pavlinac Dodig, Ivana ; Pecotić, Renata ; Valić, Maja ; Đogaš, Zoran
Izvornik
Journal of sleep research (0962-1105) 21
(2012), 2;
195-203
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
serotonin; phrenic nerve; long term facilitation; respiratory plasticity; sleep apnea
Sažetak
Obstructive sleep apnea (OSA) is characterized by periods of upper airway collapse accompanied by repeated episodes of hypoxia. In experimental animals repeated bouts of hypoxia may evoke sustained augmentation of phrenic nerve activity, known as phrenic long term facilitation (pLTF). This form of physiological compensation might contribute to a stable breathing minimizing the occurrence of apneas and/or hypopneas during sleep in patients with OSA. Serotonin (5-HT) has been shown to modulate respiratory neuronal activity, possibly via projections originating in the raphe nuclei. Our model focuses on effects of 5-HT1A receptors blockade by selective antagonist WAY-100635 into the caudal raphe region on phrenic long term facilitation after exposure to acute intermittent hypoxia (AIH) episodes. Adult, male, urethane- anesthetized, vagotomized, paralyzed, and mechanically ventilated Sprague-Dawley rats were exposed to AIH protocol. Experimental group received microinjection of WAY-100635 into the caudal raphe nucleus, whereas control group received saline into the same site. Peak phrenic nerve activity and respiratory rhythm parameters were analyzed during five hypoxic episodes, as well as at 15, 30, and 60 minutes after the end of hypoxias. In the control group, one hour post-hypoxia pLTF was developed. Microinjections of selective 5-HT1A receptor antagonist WAY- 100635 into the raphe nuclei prior to AIH protocol prevented induction of pLTF. These results suggest that 5-HT1A receptor activation at supraspinal level is important for induction of pLTF which is suggested to be an important respiratory neuroplasticity model in animal studies that possibly correlates with OSA in humans.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
216-2163166-0513 - Neuralna kontrola disanja u budnosti i spavanju (Đogaš, Zoran, MZOS ) ( CroRIS)
216-2163166-3342 - Središnja regulacija kardiovaskularnog i respiracijskog sustava-uloga serotonina (Valić, Maja, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Split
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE