Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 536314

Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT(1A) receptor in the caudal raphe region of the rat


Pavlinac Dodig, Ivana; Pecotić, Renata; Valić, Maja; Đogaš, Zoran
Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT(1A) receptor in the caudal raphe region of the rat // Journal of sleep research, 21 (2012), 2; 195-203 doi:10.1111/j.1365-2869.2011.00948.x (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 536314 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT(1A) receptor in the caudal raphe region of the rat

Autori
Pavlinac Dodig, Ivana ; Pecotić, Renata ; Valić, Maja ; Đogaš, Zoran

Izvornik
Journal of sleep research (0962-1105) 21 (2012), 2; 195-203

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
serotonin; phrenic nerve; long term facilitation; respiratory plasticity; sleep apnea

Sažetak
Obstructive sleep apnea (OSA) is characterized by periods of upper airway collapse accompanied by repeated episodes of hypoxia. In experimental animals repeated bouts of hypoxia may evoke sustained augmentation of phrenic nerve activity, known as phrenic long term facilitation (pLTF). This form of physiological compensation might contribute to a stable breathing minimizing the occurrence of apneas and/or hypopneas during sleep in patients with OSA. Serotonin (5-HT) has been shown to modulate respiratory neuronal activity, possibly via projections originating in the raphe nuclei. Our model focuses on effects of 5-HT1A receptors blockade by selective antagonist WAY-100635 into the caudal raphe region on phrenic long term facilitation after exposure to acute intermittent hypoxia (AIH) episodes. Adult, male, urethane- anesthetized, vagotomized, paralyzed, and mechanically ventilated Sprague-Dawley rats were exposed to AIH protocol. Experimental group received microinjection of WAY-100635 into the caudal raphe nucleus, whereas control group received saline into the same site. Peak phrenic nerve activity and respiratory rhythm parameters were analyzed during five hypoxic episodes, as well as at 15, 30, and 60 minutes after the end of hypoxias. In the control group, one hour post-hypoxia pLTF was developed. Microinjections of selective 5-HT1A receptor antagonist WAY- 100635 into the raphe nuclei prior to AIH protocol prevented induction of pLTF. These results suggest that 5-HT1A receptor activation at supraspinal level is important for induction of pLTF which is suggested to be an important respiratory neuroplasticity model in animal studies that possibly correlates with OSA in humans.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
216-2163166-0513 - Neuralna kontrola disanja u budnosti i spavanju (Đogaš, Zoran, MZOS ) ( CroRIS)
216-2163166-3342 - Središnja regulacija kardiovaskularnog i respiracijskog sustava-uloga serotonina (Valić, Maja, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Profili:

Avatar Url Maja Valić (autor)

Avatar Url Renata Pecotić (autor)

Avatar Url Zoran Đogaš (autor)

Avatar Url Ivana Pavlinac Dodig (autor)

Poveznice na cjeloviti tekst rada:

doi onlinelibrary.wiley.com

Citiraj ovu publikaciju:

Pavlinac Dodig, Ivana; Pecotić, Renata; Valić, Maja; Đogaš, Zoran
Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT(1A) receptor in the caudal raphe region of the rat // Journal of sleep research, 21 (2012), 2; 195-203 doi:10.1111/j.1365-2869.2011.00948.x (međunarodna recenzija, članak, znanstveni)
Pavlinac Dodig, I., Pecotić, R., Valić, M. & Đogaš, Z. (2012) Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT(1A) receptor in the caudal raphe region of the rat. Journal of sleep research, 21 (2), 195-203 doi:10.1111/j.1365-2869.2011.00948.x.
@article{article, author = {Pavlinac Dodig, Ivana and Pecoti\'{c}, Renata and Vali\'{c}, Maja and \DJoga\v{s}, Zoran}, year = {2012}, pages = {195-203}, DOI = {10.1111/j.1365-2869.2011.00948.x}, keywords = {serotonin, phrenic nerve, long term facilitation, respiratory plasticity, sleep apnea}, journal = {Journal of sleep research}, doi = {10.1111/j.1365-2869.2011.00948.x}, volume = {21}, number = {2}, issn = {0962-1105}, title = {Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT(1A) receptor in the caudal raphe region of the rat}, keyword = {serotonin, phrenic nerve, long term facilitation, respiratory plasticity, sleep apnea} }
@article{article, author = {Pavlinac Dodig, Ivana and Pecoti\'{c}, Renata and Vali\'{c}, Maja and \DJoga\v{s}, Zoran}, year = {2012}, pages = {195-203}, DOI = {10.1111/j.1365-2869.2011.00948.x}, keywords = {serotonin, phrenic nerve, long term facilitation, respiratory plasticity, sleep apnea}, journal = {Journal of sleep research}, doi = {10.1111/j.1365-2869.2011.00948.x}, volume = {21}, number = {2}, issn = {0962-1105}, title = {Acute intermittent hypoxia induces phrenic long-term facilitation which is modulated by 5-HT(1A) receptor in the caudal raphe region of the rat}, keyword = {serotonin, phrenic nerve, long term facilitation, respiratory plasticity, sleep apnea} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font