Naslov
Chronic low-grade inflammation biomarkers associated with cardiovascular disease in war prisoners

Autori
Jergović, Mladen ; Vidović, Anđelko ; Gotovac, Katja ; Sabioncello, Ante ; Kuzman, Ilija ; Henigsberg, Neven ; Lončar, Mladen ; Čeljuska, Elvira ; Dijanić Plašć, Ivana ; Rabatić, Sabina ; Dekaris, Dragan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / - , 2009, 33-33

Skup
2009 Annual Meeting of the Croatian Immunological Society

Mjesto i datum
Starigrad, Hrvatska, 01.10.2009. - 04.10.2009

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
cardiovascular disease; low-grade inflammation; inflammatory biomarkers; PTSD

Sažetak
There is growing evidence that individuals with posttraumatic stress disorder (PTSD) are at higher risk of developing coronary heart disease. PTSD is associated with neuroendocrine alterations which could contribute to initiation and development of atherosclerosis, thereby leading to cardiovascular disease (CVD). Studies have shown that PTSD is linked with the chronic low-grade inflammation which could be associated with systemic vascular inflammation and atherogenesis. In line with these notions, we have measured seven inflammatory markers involved in pathogenesis of atherosclerosis in detainees that were imprisoned in war camps during the war in Croatia. Two of these markers are primarily related to plate-let activation (sCD40L, sP-selectin) while MCP-1 and IL-8 represent chemokines responsible for recruitment of inflammatory cells to vessel walls. sVCAM-1 is a member of adhesion molecules and tPA reflects fibrinolytic activity. IL-6 is one of the major pro-inflammatory cytokines that plays a significant role in virtually all stages of the inflammatory response. A total of 72 male detainees imprisoned in war camps during 1991 and 1992 (detention lasting from 6 to 332 days) were examined in 2007. All the participants underwent thorough clinical examination including psychiatric examination and psychometric testing. All the relevant demographic data were recorded and every participant was examined (including laboratory testing) for the presence of traditional CVD risk factors. For this purpose body mass index, blood pressure, blood glucose, and serum lipids levels were determined. Most of the participants were diagnosed with PTSD according to ICD-10 and DSM-IV criteria. Analysis of association of PTSD diagnosis and PTSD related symptoms with measured inflammatory markers will be presented and discussed. Life-style related variables, as well as other identified CVD risk factors will be taken into account in all analyses.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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