Cognitive performance in asymptomatic patients with advanced carotid disease

Martinić Popović, Irena; Lovrenčić-Huzjan, Arijana; Šimundić, Ana-Maria; Popović, Alek; Šerić, Vesna; Demarin, Vida

doi:10.1097/WNN.0b013e3182313020

Pregled bibliografske jedinice broj: 533954

Cognitive performance in asymptomatic patients with advanced carotid disease

Martinić Popović, Irena; Lovrenčić-Huzjan, Arijana; Šimundić, Ana-Maria; Popović, Alek; Šerić, Vesna; Demarin, Vida

Cognitive performance in asymptomatic patients with advanced carotid disease // Cognitive and behavioral neurology, 24 (2011), 3; 145-151 doi:10.1097/WNN.0b013e3182313020 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 533954 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cognitive performance in asymptomatic patients with advanced carotid disease

Autori
Martinić Popović, Irena ; Lovrenčić-Huzjan, Arijana ; Šimundić, Ana-Maria ; Popović, Alek ; Šerić, Vesna ; Demarin, Vida

Izvornik
Cognitive and behavioral neurology (1543-3633) 24 (2011), 3; 145-151

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cognitive impairment ; carotid artery ; atherosclerosis

Sažetak
In the absence of stroke or transient ischemic attack, patients with advanced carotid stenosis or occlusion (ICAs/o) are considered asymptomatic, yet they are prone to mostly subtle cognitive impairment. The Mini-Mental State Examination (MMSE) often fails to detect mild cognitive impairment. The Montreal Cognitive Assessment (MoCA) is more sensitive in recognizing such changes. Scores on the MoCA and MMSE were compared in 70 asymptomatic patients with ICAs/o and 70 controls matched for demographic variables and vascular risk factors. MMSE scores fell mostly within the normal range in both patients and controls. Differences were significant for total MoCA scores (P<0.001). Patients with ICAs/o performed worse on visuospatial and executive function (P=0.018), abstraction (P<0.001), and delayed recall (P<0.001). Lower MoCA scores were associated with diabetes (odds ratio=6.41 ; 95% confidence interval, 1.277-32.220 ; P=0.024) and older age (odds ratio=0.86 ; 95% confidence interval, 0.780- 0.956 ; P=0.004). Patients with diabetes performed worse on delayed recall (P<0.001), and patients with hypertension were worse on the MoCA naming subtest (P=0.04). The MoCA successfully identified reduced cognitive status in patients with ICAs/o. The MoCA subtest scores revealed a pattern of cognitive impairment similar to that documented in other studies using more extensive neuropsychological tests. MoCA could be used as part of the clinical evaluation of patients with ICAs/o.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA

Projekti:
134-0000000-3381 - Promjene bubrežne arterije u bolesnika s karcinomom bubrega (Čupić, Hrvoje, MZOS ) ( CroRIS)
134-1340036-0033 - Uloga genetskih markera u razvoju cerebralne aterosklerotske bolesti (Demarin, Vida, MZOS ) ( CroRIS)
134-1340036-0034 - Funkcijska dijagnostika moždane cirkulacije (Lovrenčić-Huzjan, Arijana, MZOS ) ( CroRIS)
134-1340036-0035 - Uloga vaskularnih čimbenika rizika u patogenezi Alzheimerove bolesti (Trkanjec, Zlatko, MZOS ) ( CroRIS)
134-1340227-0200 - Upala i udio farmakogenetike u razvoju i ishodu akutnih i kroničnih bolesti (Šimundić, Ana-Maria, MZOS ) ( CroRIS)
143-1080002-0050 - Dijagnostika i liječenje bolesnika sa sindromom prostatitisa (Škerk, Višnja, MZOS ) ( CroRIS)
022-1340036-2083 - Frontotemporalne demencije (Liščić, Rajka, MZOS ) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
KBC "Sestre Milosrdnice",
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Profili:

Vida Demarin (autor)