Naslov
Quantitative analysis of placental terminal villi from growth-restricted pregnancies

Autori
Grbeša Đurđica, Fudurić Ivan, Novački Mirela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Life Sciences 2000 / Ida Eržen, Draga Štiblar-Martinčić - Ljubljana : Slovenian Society for Stereology and Quantitative Image Analysis, 2000

Skup
Life Sciences 2000

Mjesto i datum
Gozd Martuljek, Slovenija, 28.09.2000. - 01.10.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
intrauterine growth restriction; placenta; terminal villi; stereology

Sažetak
A balanced development of the uteroplacental and fetoplacental circulations is essential to ensure the fetal demands for oxygen. Villous development is dependent upon local oxygen conditions. Any disturbance of the circulatory balance will affect maturation of terminal villi and maternofetal oxygen transfer. Fetal growth restriction is associated with abnormalities in placental growth and umbilical blood flow. The knowledge of the symmetris intrauterine growth restriction (IUGR) causes and the infant,s prognosis is still limited. According to the clinical findings in the symmetric type of IUGR the cause acts during the first trimester of gestation. The growth-restricted infants are shorter and lighter compared with newborns with appropriate growth. The aim of this study was to examined structure of terminal villi and their vessels in placentas of growth-restricted fetuses by the application of stereologic methods. We examined five term placentas of intrauterine growth-restricted fetuses and five placentas of gestational age-matched control cases (38 to 41 weeks of gestation). Immediatelly upon delivery we measured newborn lenght and birthweight. We also weighed its placenta without cord and fetal membrane. The stereological analyses were made by multipurpose test system M42 (Weibel). Student t-tests were performed to test for differences between the groups. The results of the investigation show: a) the newborn length and birthweight were significantly higher in the control group (P lower 0.0005); b) the volume density of terminal villi was significantly higher in the control group of placentas (P lower 0.0005); c) the volume densities of villous trophoblast in both groups of placentas were not significantly different (P higher 0.05); d) the volume density of villous blood vessels was significantly higher in the IUGR placentas (P lower 0.0005). IUGR is the only form of disturbed gestation with increased fetoplacental blood flow resistance. The quantitative changes of terminal villi and their blood vessels in the examined IUGR placentas probably represent the response of placenta to the postplacental hypoxia.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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