Naslov
Screening for acetylcholinesterase inhibition and antioxidant activity of selected plants from Croatia

Autori
Jukić, Mila ; Burčul, Franko ; Carev, Ivana ; Politeo, Olivera ; Miloš, Mladen

Izvornik
NATURAL PRODUCT RESEARCH (1478-6419) 26 (2012), 18; 1703-1707

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acetylcholinesterase ; inhibition ; antioxidants ; DPPH ; FRAP ; extracts

Sažetak
The methanol, ethyl acetate and chloroform extracts of selected Croatian plants were tested for their acetylcholinesterase (AChE) inhibition and antioxidant activity. Assessment of AChE inhibition was carried out using microplate reader at 1 mg mL⁻¹. Antioxidant capacities were determined by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging test and ferric reducing/antioxidant power assay (FRAP). Total phenol content (TPC) of extracts were determined using Folin–Ciocalteu colorimetric method. Out of 48 extracts, only methanolic extract of the <i>Salix alba</i> L. cortex exerted modest activity towards AChE, reaching 50.80% inhibition at concentration of 1 mg mL⁻¹. All the other samples tested had activity below 20%. The same extract performed the best antioxidative activity using DPPH and FRAP method, too. In essence, among all extracts used in the screening, methanolic extracts showed the best antioxidative activity as well as highest TPC.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA