Pregled bibliografske jedinice broj: 531689
Start/stop codon-like trinucleotides (CLTs) and extended clusters as new language of DNA
Start/stop codon-like trinucleotides (CLTs) and extended clusters as new language of DNA // Croatica chemica acta, 84 (2011), 2; 331-341 doi:10.5562/cca1948 (podatak o recenziji nije dostupan, prethodno priopćenje, znanstveni)
CROSBI ID: 531689 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Start/stop codon-like trinucleotides (CLTs) and extended clusters as new language of DNA
Autori
Rosandić, Marija ; Glunčić, Matko ; Paar, Vladimir
Izvornik
Croatica chemica acta (0011-1643) 84
(2011), 2;
331-341
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prethodno priopćenje, znanstveni
Ključne riječi
alpha satellites; start/stop codons; nucleosome; cluster extension; gene regulators
Sažetak
We introduce the extended start/stop codon-like trinucleotides (CLTs) for noncoding DNA sequences, based on trinucleotide cluster extension, generated by specific single-nucleotide multiplications. Extended cluster analysis gives rise to rich information potential as a new language of DNA ("CLT language"). The analysis of start/stop CLTs extended clusters provides qualitative and quantitative differentiation and characterization of alpha satellites, as well as of other repetitive and non-repetitive noncoding sequences. As a measure of CLT extension of DNA sequences the extension factor r is introduced. Start/stop CLTs enable a distinction of three segments within alpha satellite, the first and the second as wrapping sequences and the third as a linker. Within a linker there are no start/stop CLTs. On the basis of start/stop CLTs, it is hypothesized that these noncoding sequences may be involved in the network of gene regulators.
Izvorni jezik
Engleski
POVEZANOST RADA
Projekti:
119-0982464-1253 - KSA kompjutorsko istraživanje repeticija višeg reda i duplikona u humanom genomu (Paar, Vladimir, MZOS ) ( CroRIS)
Ustanove:
Prirodoslovno-matematički fakultet, Zagreb
