Naslov
The what, where, how and why of gene ontology - a primer for bioinformaticians

Autori
Du Plessis, Louis ; Škunca, Nives ; Dessimoz, Christopher

Izvornik
Briefings in bioinformatics (1467-5463) 12 (2011), 6; 723-735

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
gene ontology; gene annotation; semantic similarity; gene function; function prediction

Sažetak
With high-throughput technologies providing vast amounts of data, it has become more important to provide systematic, quality annotations. The Gene Ontology (GO) project is the largest resource for cataloguing gene function. Nonetheless, its use is not yet ubiquitous and is still fraught with pitfalls. In this review, we provide a short primer to the GO for bioinformaticians. We summarize important aspects of the structure of the ontology, describe sources and types of functional annotations, survey measures of GO annotation similarity, review typical uses of GO and discuss other important considerations pertaining to the use of GO in bioinformatics applications.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Biotehnologija

Napomena
Special Issue: Collaborative Bioinformatics and RNA Analysis

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