Naslov
How can viruses teach us to make better vaccines and vaccine vectors

Autori
Jonjić, Stipan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, pp prezentacija, znanstveni

Skup
7th ISABS Conference in Forensic, Anthropological and Medical Genetics and Mayo Clinic Lectures in Translational Medicine

Mjesto i datum
Bol, Hrvatska, 20.06.2011. - 24.06.2011

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Viral immunosurveillance; immunoevasion; vaccines; vaccine vectors; cytomegalovirus

Sažetak
To avoid control by various immune control mechanisms, many viruses encode immunoevasin proteins. NKG2D is a potent activating receptor expressed by cells of innate and adaptive immunity. It is well established that signaling via NKG2D receptor plays an important role in control of cytomegalovirus (CMV) infection. Its importance in CMV immunosurveillance is best illustrated by numerous viral evasion mechanisms evolved to avoid NKG2D. Deletion of viral genes involved in downregulation of cellular ligands for this receptor resulted in virus attenuation in vivo. In order to circumvent CMV immunoevasion of NKG2D, we generated recombinant mouse CMV expressing cellular ligand for NKG2D receptor. This resulted in profound virus attenuation in vivo and lower latent virus DNA load. Surprisingly, despite tight innate immune control, virus expressing NKG2D ligand elicited strong, long-lasting protective immunity, suggesting that similar approaches can be used for development of a safe and immunogenic CMV vaccine. The potential of this and similar types of recombinant viruses as vaccines, or vaccine vectors, will be discussed in my talk.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA