Pregled bibliografske jedinice broj: 521653
Prognostic value of nuclear area in intestinal type of gastric cancer
Prognostic value of nuclear area in intestinal type of gastric cancer // Periodicum Biologorum, 113 (2011), 1; 103-107 (međunarodna recenzija, kratko priopcenje, znanstveni)
CROSBI ID: 521653 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Prognostic value of nuclear area in intestinal type of gastric cancer
Autori
Kovač, Dražen ; Jašić, Mladen ; Pernjak Pugel, Ester ; Grbas, Harry ; Mijandrušić Sinčić, Brankica
Izvornik
Periodicum Biologorum (0031-5362) 113
(2011), 1;
103-107
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni
Ključne riječi
Gastric cancer ; Morphometric analysis ; Nuclear area ; Survival
Sažetak
Background and purpose: The incidence of gastric cancer decreases but despite declining, it still remains the second cause of death of all malignancies worldwide. Morphometric methods are independent prognostic variables in various cancers and there have been encouraging results in using it for estimating the prognosis of gastric cancer. Aim of this study was to evaluate the influence of nuclear area (morphometric method), on the survival of patients with intestinal type of gastric cancer. Materials and methods: Seventy-four patients who had undergone gastric resections for adenocarcinoma of the stomach in the University Hospital Center, Rijeka, Croatia, were analyzed in this study. None had received pre-operative radiotherapy or chemotherapy. Age, gender, tumor size, tumor depth into the stomach wall (T-category) presence or absence of metastases to regional lymph nodes (N- category) or distant organs (M-category) and nuclear area of tumor cells were estimated. All patients were followed up for at least 36 months or to death. Results: Univariate analysis showed that gender (P = 0.009), nuclear area (P = 0.017), TNM (P = 0.001) and size of the tumor (P = 0.024) have influence on the survival. Patients age at the time of diagnosis showed no influence on the survival in univariate analysis (P = 0.089). In multivariate analysis only TNM (P=0.048) and size of the tumor (P=0.020) are independent prognostic factors for planning further therapy. Conclusions: According to our results, reliable prognostic factors in patients with intestinal type of gastric cancer are still TNM and size of the tumor ; nuclear area showed no influence on the outcome of the disease.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
062-0000000-0219 - Genetsko testiranje bolesnika s kroničnim bolestima tankoga crijeva (Mijandrušić-Sinčić, Brankica, MZOS ) ( CroRIS)
062-0621261-1269 - Perinatalni citomegalovirusni encefalitis (Pernjak-Pugel, Ester, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Mladen Jašić (autor)
Harry Grbas (autor)
Dražen Kovačević (autor)
Ester Pernjak-Pugel (autor)
Brankica Mijandrušić-Sinčić (autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
Uključenost u ostale bibliografske baze podataka::
- EMBASE (Excerpta Medica)